AICDA [The Human Chemical-Genetic Interaction Map Project]

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======= AICDA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AICDA
  * **<color #00a2e8>Official Name</color>**: activation induced cytidine deaminase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57379|57379]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZX7|Q9GZX7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AICDA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AICDA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605257|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). {ECO:0000269|PubMed:18722174, ECO:0000269|PubMed:21385873, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21518874, ECO:0000269|PubMed:27716525}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|APOBEC N|
|APOBEC C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of methylation-dependent chromatin silencing|
|DNA cytosine deamination|
|cytidine to uridine editing|
|cytidine deaminase activity|
|cytidine deamination|
|cytidine catabolic process|
|cytidine metabolic process|
|DNA deamination|
|pyrimidine ribonucleoside catabolic process|
|regulation of methylation-dependent chromatin silencing|
|pyrimidine ribonucleoside metabolic process|
|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|
|regulation of nuclear cell cycle DNA replication|
|regulation of single stranded viral RNA replication via double stranded DNA intermediate|
|somatic hypermutation of immunoglobulin genes|
|somatic recombination of immunoglobulin genes involved in immune response|
|isotype switching|
|somatic diversification of immunoglobulins involved in immune response|
|DNA demethylation|
|somatic diversification of immune receptors via somatic mutation|
|negative regulation of chromatin silencing|
|base conversion or substitution editing|
|pyrimidine nucleoside catabolic process|
|regulation of transposition|
|negative regulation of transposition|
|ribonucleoside catabolic process|
|somatic recombination of immunoglobulin gene segments|
|DNA dealkylation|
|immunoglobulin production involved in immunoglobulin mediated immune response|
|nucleoside catabolic process|
|somatic diversification of immune receptors via germline recombination within a single locus|
|somatic cell DNA recombination|
|negative regulation of gene silencing|
|somatic diversification of immunoglobulins|
|pyrimidine nucleoside metabolic process|
|regulation of chromatin silencing|
|B cell activation involved in immune response|
|pyrimidine-containing compound catabolic process|
|glycosyl compound catabolic process|
|somatic diversification of immune receptors|
|nucleobase-containing small molecule catabolic process|
|regulation of DNA-dependent DNA replication|
|negative regulation of viral genome replication|
|negative regulation of chromatin organization|
|positive regulation of gene expression, epigenetic|
|demethylation|
|DNA methylation or demethylation|
|ribonucleoside metabolic process|
|negative regulation of viral life cycle|
|P-body|
|DNA modification|
|regulation of viral genome replication|
|negative regulation of viral process|
|pyrimidine-containing compound metabolic process|
|B cell differentiation|
|nucleoside metabolic process|
|regulation of DNA replication|
|lymphocyte activation involved in immune response|
|regulation of gene silencing|
|negative regulation of chromosome organization|
|glycosyl compound metabolic process|
|regulation of viral life cycle|
|B cell activation|
|immunoglobulin production|
|RNA modification|
|production of molecular mediator of immune response|
|cellular response to lipopolysaccharide|
|regulation of chromatin organization|
|defense response to virus|
|carbohydrate derivative catabolic process|
|cellular response to molecule of bacterial origin|
|regulation of viral process|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|cellular response to biotic stimulus|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|DNA recombination|
|regulation of gene expression, epigenetic|
|lymphocyte differentiation|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to virus|
|ubiquitin protein ligase binding|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|defense response to bacterium|
|leukocyte differentiation|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|nucleobase-containing compound catabolic process|
|lymphocyte activation|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|cellular response to lipid|
|nucleobase-containing small molecule metabolic process|
|hemopoiesis|
|protein-containing complex|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|response to bacterium|
|mRNA metabolic process|
|negative regulation of cellular component organization|
|DNA metabolic process|
|regulation of cell cycle process|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|zinc ion binding|
|response to lipid|
|RNA processing|
|leukocyte activation|
|defense response to other organism|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|identical protein binding|
|cell activation|
|immune effector process|
|regulation of cell cycle|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.81|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.77|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.76|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10178
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AICDA Expression in NALM6 Cells: 2.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>