AICDA

Gene Information

Official Symbol: AICDA
Official Name: activation induced cytidine deaminase
Aliases and Previous Symbols: N/A
Entrez ID: 57379
UniProt: Q9GZX7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009].
UniProt Summary: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). {ECO:0000269|PubMed:18722174, ECO:0000269|PubMed:21385873, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21518874, ECO:0000269|PubMed:27716525}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10178
Expression level (log2 read counts): 2.15

Expression Distribution

Screen	Score
DABN racemic mixture R03 exp93	-1.81
Milciclib 2μM R08 exp502	-1.77
VER-155008 3.9μM R06 exp301	-1.76
RS-1 10μM R08 exp519	1.89

APOBEC N
APOBEC C

negative regulation of methylation-dependent chromatin silencing
DNA cytosine deamination
cytidine to uridine editing
cytidine deaminase activity
cytidine deamination
cytidine catabolic process
cytidine metabolic process
DNA deamination
pyrimidine ribonucleoside catabolic process
regulation of methylation-dependent chromatin silencing
pyrimidine ribonucleoside metabolic process
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
regulation of nuclear cell cycle DNA replication
regulation of single stranded viral RNA replication via double stranded DNA intermediate
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin genes involved in immune response
isotype switching
somatic diversification of immunoglobulins involved in immune response
DNA demethylation
somatic diversification of immune receptors via somatic mutation
negative regulation of chromatin silencing
base conversion or substitution editing
pyrimidine nucleoside catabolic process
regulation of transposition
negative regulation of transposition
ribonucleoside catabolic process
somatic recombination of immunoglobulin gene segments
DNA dealkylation
immunoglobulin production involved in immunoglobulin mediated immune response
nucleoside catabolic process
somatic diversification of immune receptors via germline recombination within a single locus
somatic cell DNA recombination
negative regulation of gene silencing
somatic diversification of immunoglobulins
pyrimidine nucleoside metabolic process
regulation of chromatin silencing
B cell activation involved in immune response
pyrimidine-containing compound catabolic process
glycosyl compound catabolic process
somatic diversification of immune receptors