AIF1 [The Human Chemical-Genetic Interaction Map Project]

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======= AIF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AIF1
  * **<color #00a2e8>Official Name</color>**: allograft inflammatory factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=199|199]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55008|P55008]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AIF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AIF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601833|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. {ECO:0000269|PubMed:15117732, ECO:0000269|PubMed:16049345, ECO:0000269|PubMed:18699778}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of muscle hyperplasia|
|regulation of muscle hyperplasia|
|positive regulation of smooth muscle cell chemotaxis|
|negative regulation of smooth muscle cell chemotaxis|
|cellular response to morphine|
|cellular response to isoquinoline alkaloid|
|positive regulation of fibroblast growth factor production|
|positive regulation of muscle adaptation|
|regulation of smooth muscle cell chemotaxis|
|parallel actin filament bundle assembly|
|cellular response to hydroperoxide|
|regulation of fibroblast growth factor production|
|actin crosslink formation|
|ruffle assembly|
|positive regulation of chemokine secretion|
|regulation of chemokine secretion|
|positive regulation of monocyte chemotaxis|
|response to hydroperoxide|
|Rac protein signal transduction|
|negative regulation of smooth muscle cell migration|
|positive regulation of mononuclear cell migration|
|ruffle organization|
|regulation of monocyte chemotaxis|
|phagocytic cup|
|leukocyte activation involved in inflammatory response|
|microglial cell activation|
|positive regulation of T cell migration|
|actin filament polymerization|
|positive regulation of interleukin-6 secretion|
|response to morphine|
|response to isoquinoline alkaloid|
|cellular response to alkaloid|
|positive regulation of G1/S transition of mitotic cell cycle|
|positive regulation of smooth muscle cell migration|
|positive regulation of lymphocyte migration|
|glial cell activation|
|positive regulation of nitric oxide biosynthetic process|
|positive regulation of nitric oxide metabolic process|
|neuroinflammatory response|
|response to electrical stimulus|
|regulation of T cell migration|
|negative regulation of smooth muscle cell proliferation|
|regulation of mononuclear cell migration|
|positive regulation of cell cycle G1/S phase transition|
|response to axon injury|
|macrophage activation|
|actin polymerization or depolymerization|
|positive regulation of reactive oxygen species biosynthetic process|
|positive regulation of chemokine production|
|regulation of nitric oxide biosynthetic process|
|negative regulation of chemotaxis|
|regulation of smooth muscle cell migration|
|regulation of lymphocyte migration|
|actin filament bundle assembly|
|actin filament bundle organization|
|positive regulation of mitotic cell cycle phase transition|
|response to anesthetic|
|regulation of chemokine production|
|actin filament|
|regulation of muscle adaptation|
|regulation of reactive oxygen species biosynthetic process|
|positive regulation of smooth muscle cell proliferation|
|protein polymerization|
|positive regulation of leukocyte chemotaxis|
|ruffle|
|positive regulation of cell cycle phase transition|
|positive regulation of interleukin-6 production|
|positive regulation of T cell proliferation|
|positive regulation of reactive oxygen species metabolic process|
|ruffle membrane|
|cell projection|
|cerebellum development|
|metencephalon development|
|regulation of leukocyte chemotaxis|
|response to alkaloid|
|phagocytosis, engulfment|
|positive regulation of leukocyte migration|
|positive regulation of lymphocyte proliferation|
|cellular response to ammonium ion|
|positive regulation of mononuclear cell proliferation|
|regulation of smooth muscle cell proliferation|
|perikaryon|
|positive regulation of chemotaxis|
|positive regulation of leukocyte proliferation|
|plasma membrane invagination|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|response to glucocorticoid|
|membrane invagination|
|cytokine production|
|regulation of G1/S transition of mitotic cell cycle|
|hindbrain development|
|positive regulation of mitotic cell cycle|
|regulation of T cell proliferation|
|response to corticosteroid|
|cellular response to interferon-gamma|
|regulation of cell cycle G1/S phase transition|
|regulation of reactive oxygen species metabolic process|
|lamellipodium|
|response to interferon-gamma|
|response to ammonium ion|
|cellular response to xenobiotic stimulus|
|regulation of leukocyte migration|
|positive regulation of T cell activation|
|actin filament binding|
|regulation of cytokine secretion|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of chemotaxis|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|regulation of muscle system process|
|cellular response to oxidative stress|
|actin filament organization|
|Ras protein signal transduction|
|positive regulation of cell-cell adhesion|
|negative regulation of cell migration|
|cellular response to extracellular stimulus|
|positive regulation of protein secretion|
|negative regulation of cell motility|
|positive regulation of cell cycle process|
|positive regulation of peptide secretion|
|regulation of leukocyte cell-cell adhesion|
|response to xenobiotic stimulus|
|negative regulation of cellular component movement|
|regulation of T cell activation|
|small GTPase mediated signal transduction|
|negative regulation of locomotion|
|response to steroid hormone|
|phagocytosis|
|cellular response to external stimulus|
|regulation of neurotransmitter levels|
|positive regulation of lymphocyte activation|
|negative regulation of response to external stimulus|
|positive regulation of cell cycle|
|response to oxidative stress|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|cellular response to drug|
|regulation of mitotic cell cycle phase transition|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|positive regulation of cytokine production|
|supramolecular fiber organization|
|cell projection assembly|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|actin cytoskeleton organization|
|inflammatory response|
|positive regulation of cell migration|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|response to extracellular stimulus|
|positive regulation of cellular component movement|
|cellular response to organic cyclic compound|
|positive regulation of locomotion|
|endocytosis|
|actin filament-based process|
|response to wounding|
|myeloid leukocyte activation|
|regulation of system process|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|import into cell|
|regulation of cell adhesion|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|calcium ion binding|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|molecular function|
|innate immune response|
|head development|
|regulation of secretion|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|membrane organization|
|response to lipid|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|leukocyte activation|
|defense response to other organism|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|response to drug|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|cell projection organization|
|response to abiotic stimulus|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11857
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AIF1 Expression in NALM6 Cells: -2.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>