AIF1
Gene Information
- Official Symbol: AIF1
- Official Name: allograft inflammatory factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 199
- UniProt: P55008
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. {ECO:0000269|PubMed:15117732, ECO:0000269|PubMed:16049345, ECO:0000269|PubMed:18699778}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| positive regulation of muscle hyperplasia |
| regulation of muscle hyperplasia |
| positive regulation of smooth muscle cell chemotaxis |
| negative regulation of smooth muscle cell chemotaxis |
| cellular response to morphine |
| cellular response to isoquinoline alkaloid |
| positive regulation of fibroblast growth factor production |
| positive regulation of muscle adaptation |
| regulation of smooth muscle cell chemotaxis |
| parallel actin filament bundle assembly |
| cellular response to hydroperoxide |
| regulation of fibroblast growth factor production |
| actin crosslink formation |
| ruffle assembly |
| positive regulation of chemokine secretion |
| regulation of chemokine secretion |
| positive regulation of monocyte chemotaxis |
| response to hydroperoxide |
| Rac protein signal transduction |
| negative regulation of smooth muscle cell migration |
| positive regulation of mononuclear cell migration |
| ruffle organization |
| regulation of monocyte chemotaxis |
| phagocytic cup |
| leukocyte activation involved in inflammatory response |
| microglial cell activation |
| positive regulation of T cell migration |
| actin filament polymerization |
| positive regulation of interleukin-6 secretion |
| response to morphine |
| response to isoquinoline alkaloid |
| cellular response to alkaloid |
| positive regulation of G1/S transition of mitotic cell cycle |
| positive regulation of smooth muscle cell migration |
| positive regulation of lymphocyte migration |
| glial cell activation |
| positive regulation of nitric oxide biosynthetic process |
| positive regulation of nitric oxide metabolic process |
| neuroinflammatory response |
| response to electrical stimulus |
| regulation of T cell migration |
| negative regulation of smooth muscle cell proliferation |
| regulation of mononuclear cell migration |
| positive regulation of cell cycle G1/S phase transition |
| response to axon injury |
| macrophage activation |
| actin polymerization or depolymerization |
| positive regulation of reactive oxygen species biosynthetic process |
| positive regulation of chemokine production |
| regulation of nitric oxide biosynthetic process |
| negative regulation of chemotaxis |
| regulation of smooth muscle cell migration |
| regulation of lymphocyte migration |
| actin filament bundle assembly |
| actin filament bundle organization |
| positive regulation of mitotic cell cycle phase transition |
| response to anesthetic |
| regulation of chemokine production |
| actin filament |
| regulation of muscle adaptation |
| regulation of reactive oxygen species biosynthetic process |
| positive regulation of smooth muscle cell proliferation |
| protein polymerization |
| positive regulation of leukocyte chemotaxis |
| ruffle |
| positive regulation of cell cycle phase transition |
| positive regulation of interleukin-6 production |
| positive regulation of T cell proliferation |
| positive regulation of reactive oxygen species metabolic process |
| ruffle membrane |
| cell projection |
| cerebellum development |
| metencephalon development |
| regulation of leukocyte chemotaxis |
| response to alkaloid |
| phagocytosis, engulfment |
| positive regulation of leukocyte migration |
| positive regulation of lymphocyte proliferation |
| cellular response to ammonium ion |
| positive regulation of mononuclear cell proliferation |
| regulation of smooth muscle cell proliferation |
| perikaryon |
| positive regulation of chemotaxis |
| positive regulation of leukocyte proliferation |
| plasma membrane invagination |
| positive regulation of cytokine secretion |
| regulation of interleukin-6 production |
| response to glucocorticoid |
| membrane invagination |
| cytokine production |
| regulation of G1/S transition of mitotic cell cycle |
| hindbrain development |
| positive regulation of mitotic cell cycle |
| regulation of T cell proliferation |
| response to corticosteroid |
| cellular response to interferon-gamma |
| regulation of cell cycle G1/S phase transition |
| regulation of reactive oxygen species metabolic process |
| lamellipodium |
| response to interferon-gamma |
| response to ammonium ion |
| cellular response to xenobiotic stimulus |
| regulation of leukocyte migration |
| positive regulation of T cell activation |
| actin filament binding |
| regulation of cytokine secretion |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| regulation of chemotaxis |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of leukocyte proliferation |
| regulation of muscle system process |
| cellular response to oxidative stress |
| actin filament organization |
| Ras protein signal transduction |
| positive regulation of cell-cell adhesion |
| negative regulation of cell migration |
| cellular response to extracellular stimulus |
| positive regulation of protein secretion |
| negative regulation of cell motility |
| positive regulation of cell cycle process |
| positive regulation of peptide secretion |
| regulation of leukocyte cell-cell adhesion |
| response to xenobiotic stimulus |
| negative regulation of cellular component movement |
| regulation of T cell activation |
| small GTPase mediated signal transduction |
| negative regulation of locomotion |
| response to steroid hormone |
| phagocytosis |
| cellular response to external stimulus |
| regulation of neurotransmitter levels |
| positive regulation of lymphocyte activation |
| negative regulation of response to external stimulus |
| positive regulation of cell cycle |
| response to oxidative stress |
| regulation of cell-cell adhesion |
| positive regulation of secretion by cell |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| cellular response to drug |
| regulation of mitotic cell cycle phase transition |
| positive regulation of cell activation |
| positive regulation of protein transport |
| positive regulation of secretion |
| plasma membrane bounded cell projection assembly |
| regulation of cell cycle phase transition |
| positive regulation of cytokine production |
| supramolecular fiber organization |
| cell projection assembly |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of peptide secretion |
| actin cytoskeleton organization |
| inflammatory response |
| positive regulation of cell migration |
| regulation of lymphocyte activation |
| positive regulation of cell motility |
| response to extracellular stimulus |
| positive regulation of cellular component movement |
| cellular response to organic cyclic compound |
| positive regulation of locomotion |
| endocytosis |
| actin filament-based process |
| response to wounding |
| myeloid leukocyte activation |
| regulation of system process |
| cellular response to organonitrogen compound |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| cellular response to hormone stimulus |
| regulation of mitotic cell cycle |
| regulation of cell activation |
| cellular response to nitrogen compound |
| negative regulation of cell population proliferation |
| import into cell |
| regulation of cell adhesion |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| regulation of protein transport |
| calcium ion binding |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of cell cycle process |
| molecular function |
| innate immune response |
| head development |
| regulation of secretion |
| cellular protein-containing complex assembly |
| regulation of cell migration |
| membrane organization |
| response to lipid |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| leukocyte activation |
| defense response to other organism |
| central nervous system development |
| regulation of locomotion |
| positive regulation of transport |
| negative regulation of cell death |
| regulation of cellular component movement |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| response to drug |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| cell activation |
| response to nitrogen compound |
| regulation of response to external stimulus |
| response to cytokine |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| cell projection organization |
| response to abiotic stimulus |
| regulation of cell cycle |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11857
- Expression level (log2 read counts): -2.6
Expression Distribution
AIF1 Expression in NALM6 Cells: -2.6
