AIF1L

Entrez Summary: N/A
UniProt Summary: Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function. {ECO:0000269|PubMed:18699778}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
YM155 0.0002μM R01 exp61	-1.83
VHL-ligand-1 20μM R07 exp421	-1.73

ruffle assembly
ruffle organization
actin filament bundle assembly
actin filament bundle organization
actin filament
ruffle membrane
cell projection
actin filament binding
actin cytoskeleton
actin filament organization
focal adhesion
plasma membrane bounded cell projection assembly
supramolecular fiber organization
cell projection assembly
actin cytoskeleton organization
actin filament-based process
protein-containing complex
calcium ion binding
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization