AIFM2

Entrez Summary: N/A
UniProt Summary: Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest. {ECO:0000269|PubMed:11980907, ECO:0000269|PubMed:12135761, ECO:0000269|PubMed:15958387}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Bortezomib 0.05μM R00 exp7	-1.74
Etoposide 1μM R00 exp19	-1.71

Pyr redox 2
Pyr redox

electron-transferring-flavoprotein dehydrogenase activity
flavin adenine dinucleotide binding
apoptotic mitochondrial changes
lipid droplet
respiratory electron transport chain
mitochondrial outer membrane
cellular respiration
electron transport chain
energy derivation by oxidation of organic compounds
generation of precursor metabolites and energy
mitochondrion organization
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
apoptotic process
oxidation-reduction process
programmed cell death
cell death
mitochondrion
DNA binding
regulation of apoptotic process
regulation of programmed cell death
extracellular space
regulation of cell death