AK1

Gene Information

Official Symbol: AK1
Official Name: adenylate kinase 1
Aliases and Previous Symbols: N/A
Entrez ID: 203
UniProt: P00568
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
UniProt Summary: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. {ECO:0000255|HAMAP-Rule:MF_03171, ECO:0000269|PubMed:23416111}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8065
Expression level (log2 read counts): 2.81

Expression Distribution

ADP biosynthetic process
purine nucleoside diphosphate biosynthetic process
purine ribonucleoside diphosphate biosynthetic process
ribonucleoside diphosphate biosynthetic process
adenylate kinase activity
nucleoside diphosphate biosynthetic process
nucleoside monophosphate phosphorylation
AMP metabolic process
nucleoside diphosphate kinase activity
nucleobase-containing small molecule interconversion
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
ADP metabolic process
ribonucleoside monophosphate metabolic process
nucleoside diphosphate phosphorylation
purine nucleoside diphosphate metabolic process
nucleotide phosphorylation
purine ribonucleoside diphosphate metabolic process
nucleoside triphosphate biosynthetic process
ribonucleoside diphosphate metabolic process
nucleoside monophosphate metabolic process
nucleoside diphosphate metabolic process
nucleoside triphosphate metabolic process
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
ATP metabolic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
drug metabolic process
organophosphate biosynthetic process