AK2 [The Human Chemical-Genetic Interaction Map Project]

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======= AK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AK2
  * **<color #00a2e8>Official Name</color>**: adenylate kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=204|204]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54819|P54819]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103020|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADK|
|ADK lid|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sperm mitochondrial sheath|
|ADP biosynthetic process|
|purine nucleoside diphosphate biosynthetic process|
|ribonucleoside diphosphate biosynthetic process|
|purine ribonucleoside diphosphate biosynthetic process|
|adenylate kinase activity|
|nucleoside diphosphate biosynthetic process|
|AMP metabolic process|
|nucleoside monophosphate phosphorylation|
|nucleobase-containing small molecule interconversion|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|ADP metabolic process|
|ribonucleoside monophosphate metabolic process|
|purine nucleoside diphosphate metabolic process|
|purine ribonucleoside diphosphate metabolic process|
|ribonucleoside diphosphate metabolic process|
|nucleoside monophosphate metabolic process|
|mitochondrial intermembrane space|
|nucleoside diphosphate metabolic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|ATP metabolic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.9|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.8|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.72|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.9|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.92|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.18|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|2.24|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|2.29|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.33|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.55|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.91|
|[[:results:exp211|AICAR 240μM R05 exp211]]|8.09|
|[[:results:exp116|AICAR 240μM R03 exp116]]|8.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nudt2|NUDT2]]|0.539|
|[[:human genes:m:mtr|MTR]]|0.477|
|[[:human genes:a:adss|ADSS]]|0.477|
|[[:human genes:m:mmachc|MMACHC]]|0.444|
|[[:human genes:y:ylpm1|YLPM1]]|0.421|
|[[:human genes:a:adk|ADK]]|0.412|
|[[:human genes:s:slc25a32|SLC25A32]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2747
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AK2 Expression in NALM6 Cells: 7.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>