AK2

Gene Information

Official Symbol: AK2
Official Name: adenylate kinase 2
Aliases and Previous Symbols: N/A
Entrez ID: 204
UniProt: P54819
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mubritinib 0.2μM R02 exp65	-1.9
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.8
UM131593 0.2μM R03 exp106	1.72
Epothilone-B 0.0015μM R05 exp231	1.9
Taxol 0.004μM R03 exp103	1.92
TRAIL 5ng/ml R00 exp35	2
Talazoparib 0.006μM R06 exp299	2.18
Adefovir 20μM R07 exp332	2.24
Cabazitaxel 0.001μM R05 exp223	2.29
Thapsigargin 0.005μM R07 exp407	2.33
I-BRD9 4μM R07 exp365	2.55
Aminopterin 0.005μM R07 exp335	2.91
AICAR 240μM R05 exp211	8.09
AICAR 240μM R03 exp116	8.26

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2747
Expression level (log2 read counts): 7.93

Expression Distribution

Gene	Correlation
NUDT2	0.539
MTR	0.477
ADSS	0.477
MMACHC	0.444
YLPM1	0.421
ADK	0.412
SLC25A32	0.4

sperm mitochondrial sheath
ADP biosynthetic process
purine nucleoside diphosphate biosynthetic process
ribonucleoside diphosphate biosynthetic process
purine ribonucleoside diphosphate biosynthetic process
adenylate kinase activity
nucleoside diphosphate biosynthetic process
AMP metabolic process
nucleoside monophosphate phosphorylation
nucleobase-containing small molecule interconversion
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
ADP metabolic process
ribonucleoside monophosphate metabolic process
purine nucleoside diphosphate metabolic process
purine ribonucleoside diphosphate metabolic process
ribonucleoside diphosphate metabolic process
nucleoside monophosphate metabolic process
mitochondrial intermembrane space
nucleoside diphosphate metabolic process
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
ATP metabolic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
drug metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
organophosphate metabolic process