AKAP12 [The Human Chemical-Genetic Interaction Map Project]

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======= AKAP12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AKAP12
  * **<color #00a2e8>Official Name</color>**: A-kinase anchoring protein 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9590|9590]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02952|Q02952]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AKAP12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AKAP12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604698|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WSK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of oligodendrocyte apoptotic process|
|regulation of hepatic stellate cell migration|
|positive regulation of hepatic stellate cell migration|
|hepatic stellate cell activation|
|positive regulation of glial cell apoptotic process|
|regulation of oligodendrocyte apoptotic process|
|fibroblast activation|
|regulation of glial cell apoptotic process|
|positive regulation of protein kinase A signaling|
|positive regulation of fibroblast migration|
|negative regulation of vascular permeability|
|adenylate cyclase binding|
|positive regulation of nitric-oxide synthase biosynthetic process|
|regulation of protein kinase C signaling|
|regulation of nitric-oxide synthase biosynthetic process|
|positive regulation of tumor necrosis factor biosynthetic process|
|positive regulation of tumor necrosis factor secretion|
|regulation of protein kinase A signaling|
|protein kinase A binding|
|regulation of tumor necrosis factor secretion|
|regulation of tumor necrosis factor biosynthetic process|
|regulation of fibroblast migration|
|regulation of vascular permeability|
|response to electrical stimulus|
|positive regulation of cytokine biosynthetic process|
|Schaffer collateral - CA1 synapse|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|regulation of cytokine biosynthetic process|
|cell cortex|
|positive regulation of cytokine secretion|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|vascular process in circulatory system|
|cellular response to interleukin-1|
|response to interleukin-1|
|regulation of cytokine secretion|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|positive regulation of ERK1 and ERK2 cascade|
|cellular response to tumor necrosis factor|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|response to tumor necrosis factor|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|protein targeting|
|cytoskeleton|
|neuronal cell body|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|focal adhesion|
|positive regulation of protein transport|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of secretion|
|regulation of cell migration|
|response to lipid|
|regulation of cell motility|
|regulation of locomotion|
|positive regulation of transport|
|intracellular protein transport|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|cell activation|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|regulation of protein phosphorylation|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.34|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-2.17|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.13|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.02|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.94|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.92|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.89|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.82|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.79|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.78|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.78|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.76|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.7|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.73|
|[[:results:exp453|B02 10μM R08 exp453]]|1.97|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.06|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.23|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|2.49|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19028
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AKAP12 Expression in NALM6 Cells: 8.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>