AKAP12

Gene Information

Official Symbol: AKAP12
Official Name: A-kinase anchoring protein 12
Aliases and Previous Symbols: N/A
Entrez ID: 9590
UniProt: Q02952
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
UniProt Summary: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Doxorubicin 0.02μM R08 exp478	-2.34
IU1-C 25μM R04 exp183	-2.17
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.13
Q15 1 to 2μM on day4 R04 exp164	-2.02
Milciclib 2μM R08 exp502	-1.94
Arsenate 40μM R06 exp264	-1.92
AICAR 240μM R05 exp211	-1.89
CVT-10216 0.1μM R06 exp278	-1.82
Genistein 15μM R07 exp360	-1.79
2-Methoxyestradiol 0.55μM R07 exp310	-1.78
ABT-702 0.1μM R06 exp260	-1.78
Lead acetate 2000μM R08 exp498 no dilution day6	-1.76
YM155 0.0002μM R01 exp61	-1.7
LY2090314 0.003μM R08 exp499	1.73
B02 10μM R08 exp453	1.97
Thimerosal 0.85μM R08 exp529	2.06
FK-506 30μM R07 exp359	2.23
Aphidicolin 0.04μM R06 exp263	2.49
Mubritinib 0.2μM R02 exp65	2.57

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 19028
Expression level (log2 read counts): 8.1

Expression Distribution

positive regulation of oligodendrocyte apoptotic process
regulation of hepatic stellate cell migration
positive regulation of hepatic stellate cell migration
hepatic stellate cell activation
positive regulation of glial cell apoptotic process
regulation of oligodendrocyte apoptotic process
fibroblast activation
regulation of glial cell apoptotic process
positive regulation of protein kinase A signaling
positive regulation of fibroblast migration
negative regulation of vascular permeability
adenylate cyclase binding
positive regulation of nitric-oxide synthase biosynthetic process
regulation of protein kinase C signaling
regulation of nitric-oxide synthase biosynthetic process
positive regulation of tumor necrosis factor biosynthetic process
positive regulation of tumor necrosis factor secretion
regulation of protein kinase A signaling
protein kinase A binding
regulation of tumor necrosis factor secretion
regulation of tumor necrosis factor biosynthetic process
regulation of fibroblast migration
regulation of vascular permeability
response to electrical stimulus
positive regulation of cytokine biosynthetic process
Schaffer collateral - CA1 synapse
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
positive regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor superfamily cytokine production
regulation of cytokine biosynthetic process
cell cortex
positive regulation of cytokine secretion
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
vascular process in circulatory system
cellular response to interleukin-1
response to interleukin-1
regulation of cytokine secretion
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
positive regulation of ERK1 and ERK2 cascade