AKAP4

Entrez Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
UniProt Summary: Major structural component of sperm fibrous sheath. Plays a role in sperm motility. {ECO:0000269|PubMed:9822690}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
HMS-I2 5μM R06 exp287	-1.74
MK-1775 0.32μM R02 exp75	2.04

sperm fibrous sheath
cAMP-dependent protein kinase complex
sperm principal piece
motile cilium assembly
protein kinase A binding
sperm motility
flagellated sperm motility
cilium-dependent cell motility
cilium or flagellum-dependent cell motility
motile cilium
Z disc
single fertilization
fertilization
transmembrane receptor protein serine/threonine kinase signaling pathway
cilium assembly
cytoskeleton
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
perinuclear region of cytoplasm
enzyme linked receptor protein signaling pathway
organelle assembly
sexual reproduction
multi-organism reproductive process
cell motility
localization of cell
plasma membrane bounded cell projection organization
cell projection organization
locomotion
reproductive process
reproduction
movement of cell or subcellular component
establishment of protein localization