AKR1B1
Gene Information
- Official Symbol: AKR1B1
- Official Name: aldo-keto reductase family 1 member B
- Aliases and Previous Symbols: N/A
- Entrez ID: 231
- UniProt: P15121
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pfam Domains GO Terms
Pfam Domains
| Aldo ket red |
GO Terms
| glyceraldehyde oxidoreductase activity |
| hexitol biosynthetic process |
| plasma membrane bounded cell projection cytoplasm |
| sorbitol biosynthetic process |
| cellular response to methylglyoxal |
| fructose biosynthetic process |
| naphthalene metabolic process |
| naphthalene-containing compound metabolic process |
| sorbitol metabolic process |
| Schwann cell microvillus |
| inner medullary collecting duct development |
| cellular hyperosmotic salinity response |
| response to methylglyoxal |
| hexitol metabolic process |
| allyl-alcohol dehydrogenase activity |
| alditol biosynthetic process |
| metanephric collecting duct development |
| retinal dehydrogenase activity |
| paranodal junction |
| cellular response to salt stress |
| polyketide metabolic process |
| daunorubicin metabolic process |
| doxorubicin metabolic process |
| response to water deprivation |
| hyperosmotic salinity response |
| aminoglycoside antibiotic metabolic process |
| cellular response to aldehyde |
| Schmidt-Lanterman incisure |
| cellular hyperosmotic response |
| NADP-retinol dehydrogenase activity |
| alcohol dehydrogenase (NADP+) activity |
| collecting duct development |
| norepinephrine metabolic process |
| tertiary alcohol metabolic process |
| alditol:NADP+ 1-oxidoreductase activity |
| C21-steroid hormone biosynthetic process |
| fructose metabolic process |
| response to water |
| glycoside metabolic process |
| regulation of urine volume |
| mast cell granule |
| response to salt stress |
| hyperosmotic response |
| alditol metabolic process |
| response to thyroid hormone |
| C21-steroid hormone metabolic process |
| quinone metabolic process |
| cellular response to osmotic stress |
| renal water homeostasis |
| retinol metabolic process |
| catecholamine metabolic process |
| catechol-containing compound metabolic process |
| steroid hormone biosynthetic process |
| hexose biosynthetic process |
| monosaccharide biosynthetic process |
| secondary metabolic process |
| cellular carbohydrate biosynthetic process |
| polyol biosynthetic process |
| hormone biosynthetic process |
| maternal process involved in female pregnancy |
| multicellular organismal water homeostasis |
| cellular ketone metabolic process |
| water homeostasis |
| electron transfer activity |
| primary alcohol metabolic process |
| response to osmotic stress |
| phenol-containing compound metabolic process |
| metanephros development |
| positive regulation of receptor signaling pathway via JAK-STAT |
| positive regulation of smooth muscle cell proliferation |
| positive regulation of receptor signaling pathway via STAT |
| cellular response to ketone |
| retinoid metabolic process |
| antibiotic metabolic process |
| diterpenoid metabolic process |
| polyol metabolic process |
| renal system process |
| alcohol biosynthetic process |
| oxidoreductase activity |
| terpenoid metabolic process |
| cellular hormone metabolic process |
| steroid biosynthetic process |
| carbohydrate biosynthetic process |
| regulation of receptor signaling pathway via JAK-STAT |
| regulation of smooth muscle cell proliferation |
| glycosyl compound metabolic process |
| regulation of receptor signaling pathway via STAT |
| isoprenoid metabolic process |
| stress-activated protein kinase signaling cascade |
| hexose metabolic process |
| cellular carbohydrate metabolic process |
| female pregnancy |
| electron transport chain |
| organic hydroxy compound biosynthetic process |
| tissue homeostasis |
| response to ketone |
| ammonium ion metabolic process |
| monosaccharide metabolic process |
| hormone metabolic process |
| multi-multicellular organism process |
| steroid metabolic process |
| kidney development |
| renal system development |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| alcohol metabolic process |
| urogenital system development |
| multicellular organismal homeostasis |
| cellular response to peptide |
| anatomical structure homeostasis |
| response to acid chemical |
| generation of precursor metabolites and energy |
| cofactor metabolic process |
| organic hydroxy compound metabolic process |
| response to peptide |
| carbohydrate metabolic process |
| regulation of body fluid levels |
| drug metabolic process |
| regulation of hormone levels |
| response to inorganic substance |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| cellular response to organonitrogen compound |
| cellular response to nitrogen compound |
| perinuclear region of cytoplasm |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| tube development |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| positive regulation of cell population proliferation |
| cellular lipid metabolic process |
| oxidation-reduction process |
| negative regulation of cell death |
| multi-organism reproductive process |
| response to organonitrogen compound |
| carbohydrate derivative metabolic process |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| chemical homeostasis |
| response to abiotic stimulus |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| organic cyclic compound biosynthetic process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| extracellular space |
| regulation of cell population proliferation |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| small molecule metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11779
- Expression level (log2 read counts): 7.39
Expression Distribution
AKR1B1 Expression in NALM6 Cells: 7.39
