AKR1B10

Entrez Summary: N/A
UniProt Summary: Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. {ECO:0000269|PubMed:18087047}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

geranylgeranyl reductase activity
farnesol metabolic process
sesquiterpenoid catabolic process
farnesol catabolic process
sesquiterpenoid metabolic process
indanol dehydrogenase activity
polyprenol catabolic process
allyl-alcohol dehydrogenase activity
terpenoid catabolic process
cellular detoxification of aldehyde
polyprenol metabolic process
retinal dehydrogenase activity
doxorubicin metabolic process
polyketide metabolic process
isoprenoid catabolic process
daunorubicin metabolic process
aminoglycoside antibiotic metabolic process
cellular response to aldehyde
NADP-retinol dehydrogenase activity
aldo-keto reductase (NADP) activity
alcohol dehydrogenase (NADP+) activity
tertiary alcohol metabolic process
alditol:NADP+ 1-oxidoreductase activity
primary alcohol catabolic process
glycoside metabolic process
quinone metabolic process
retinol metabolic process
antibiotic catabolic process
secondary metabolic process
alcohol catabolic process
cellular ketone metabolic process
organic hydroxy compound catabolic process
primary alcohol metabolic process
cellular detoxification
retinoid metabolic process
antibiotic metabolic process
diterpenoid metabolic process
oxidoreductase activity
terpenoid metabolic process
cellular hormone metabolic process