AKR1C3

Gene Information

Official Symbol: AKR1C3
Official Name: aldo-keto reductase family 1 member C3
Aliases and Previous Symbols: N/A
Entrez ID: 8644
UniProt: P42330
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12351
Expression level (log2 read counts): -0.75

Expression Distribution

ketoreductase activity
15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
prostaglandin D2 11-ketoreductase activity
negative regulation of isoprenoid metabolic process
negative regulation of retinoic acid biosynthetic process
prostaglandin H2 endoperoxidase reductase activity
prostaglandin-F synthase activity
dihydrotestosterone 17-beta-dehydrogenase activity
farnesol metabolic process
sesquiterpenoid metabolic process
delta4-3-oxosteroid 5beta-reductase activity
geranylgeranyl reductase activity
regulation of retinoic acid biosynthetic process
farnesol catabolic process
sesquiterpenoid catabolic process
phenanthrene 9,10-monooxygenase activity
polyprenol catabolic process
regulation of testosterone biosynthetic process
indanol dehydrogenase activity
regulation of isoprenoid metabolic process
cellular response to jasmonic acid stimulus
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
testosterone 17-beta-dehydrogenase (NADP+) activity
response to jasmonic acid
testosterone dehydrogenase (NAD+) activity
response to prostaglandin D
testosterone biosynthetic process
androsterone dehydrogenase activity
cellular response to prostaglandin D stimulus
ketosteroid monooxygenase activity
negative regulation of vitamin metabolic process
terpenoid catabolic process
polyprenol metabolic process
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
retinal dehydrogenase activity
polyketide metabolic process
daunorubicin metabolic process
doxorubicin metabolic process
isoprenoid catabolic process
aminoglycoside antibiotic metabolic process