AKR7A3

Entrez Summary: N/A
UniProt Summary: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:18416522}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mycotoxin catabolic process
organic heteropentacyclic compound catabolic process
aflatoxin catabolic process
mycotoxin metabolic process
aflatoxin metabolic process
organic heteropentacyclic compound metabolic process
toxin catabolic process
aldo-keto reductase (NADP) activity
toxin metabolic process
cellular aldehyde metabolic process
secondary metabolic process
electron transfer activity
detoxification
xenobiotic metabolic process
electron transport chain
cellular response to xenobiotic stimulus
response to xenobiotic stimulus
generation of precursor metabolites and energy
heterocycle catabolic process
organic cyclic compound catabolic process
response to toxic substance
oxidation-reduction process
identical protein binding
organic substance catabolic process
cellular catabolic process