AKTIP

Entrez Summary: N/A
UniProt Summary: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. {ECO:0000269|PubMed:14749367, ECO:0000269|PubMed:18799622}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

FHF complex
ubiquitin-like protein transferase activity
HOPS complex
early endosome to late endosome transport
vesicle-mediated transport between endosomal compartments
endosome to lysosome transport
lysosome organization
lytic vacuole organization
endosome organization
positive regulation of protein binding
lysosomal transport
vacuole organization
vacuolar transport
cytosolic transport
positive regulation of binding
regulation of protein binding
vesicle organization
regulation of binding
endomembrane system organization
apoptotic process
positive regulation of protein phosphorylation
programmed cell death
positive regulation of phosphorylation
cell death
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
positive regulation of protein modification process
regulation of protein phosphorylation
protein transport
intracellular transport
peptide transport
amide transport
regulation of phosphorylation
positive regulation of cellular protein metabolic process
establishment of protein localization
positive regulation of protein metabolic process
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
establishment of localization in cell