ALDH1L1

Entrez Summary: The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]. COMPLETENESS: complete on the 3' end.
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

hydroxymethyl-, formyl- and related transferase activity
10-formyltetrahydrofolate catabolic process
formyltetrahydrofolate dehydrogenase activity
folic acid-containing compound catabolic process
pteridine-containing compound catabolic process
10-formyltetrahydrofolate metabolic process
aldehyde dehydrogenase (NAD) activity
coenzyme catabolic process
dicarboxylic acid catabolic process
tetrahydrofolate metabolic process
folic acid metabolic process
one-carbon metabolic process
folic acid-containing compound metabolic process
cellular modified amino acid catabolic process
pteridine-containing compound metabolic process
catalytic activity
cofactor catabolic process
water-soluble vitamin metabolic process
dicarboxylic acid metabolic process
vitamin metabolic process
cellular modified amino acid metabolic process
coenzyme metabolic process
organic acid catabolic process
carboxylic acid catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
cofactor metabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
drug metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process