ALDH3A2

Entrez Summary: Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. {ECO:0000269|PubMed:22633490}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.13
RK-33 8μM R08 exp518	1.79

long-chain-aldehyde dehydrogenase activity
hexadecanal metabolic process
long-chain-alcohol oxidase activity
medium-chain-aldehyde dehydrogenase activity
phytol metabolic process
fatty alcohol metabolic process
3-chloroallyl aldehyde dehydrogenase activity
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
fatty acid alpha-oxidation
aldehyde dehydrogenase (NAD) activity
cellular aldehyde metabolic process
peroxisomal membrane
peripheral nervous system development
primary alcohol metabolic process
fatty acid oxidation
lipid oxidation
sphingolipid biosynthetic process
fatty acid catabolic process
diterpenoid metabolic process
monocarboxylic acid catabolic process
terpenoid metabolic process
membrane lipid biosynthetic process
isoprenoid metabolic process
sphingolipid metabolic process
cellular lipid catabolic process
lipid modification
membrane lipid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
lipid catabolic process
alcohol metabolic process
fatty acid metabolic process
epidermis development
small molecule catabolic process
organic hydroxy compound metabolic process
drug metabolic process
monocarboxylic acid metabolic process
lipid biosynthetic process
intracellular membrane-bounded organelle
protein homodimerization activity