ALDH9A1

Entrez Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008].
UniProt Summary: Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction. {ECO:0000269|PubMed:10702312}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nutlin-3A 1.6μM R06 exp294	-2.03
CI-1040 9.5μM R08 exp472	-2.02

1-pyrroline dehydrogenase activity
aminobutyraldehyde dehydrogenase activity
4-trimethylammoniobutyraldehyde dehydrogenase activity
carnitine biosynthetic process
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
amino-acid betaine biosynthetic process
aldehyde dehydrogenase (NAD) activity
carnitine metabolic process
amino-acid betaine metabolic process
neurotransmitter biosynthetic process
cellular modified amino acid biosynthetic process
cellular aldehyde metabolic process
neurotransmitter metabolic process
protein homotetramerization
protein tetramerization
ammonium ion metabolic process
cellular modified amino acid metabolic process
hormone metabolic process
protein homooligomerization
regulation of neurotransmitter levels
protein complex oligomerization
regulation of hormone levels
oxidation-reduction process
organonitrogen compound biosynthetic process
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
protein-containing complex subunit organization