ALG10B [The Human Chemical-Genetic Interaction Map Project]

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======= ALG10B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALG10B
  * **<color #00a2e8>Official Name</color>**: ALG10 alpha-1,2-glucosyltransferase B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=144245|144245]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5I7T1|Q5I7T1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALG10B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALG10B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603313|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 (PubMed:14525949). Has a role in maintenance of cochlear outer hair cell function (By similarity). {ECO:0000250|UniProtKB:P50076, ECO:0000250|UniProtKB:Q3UGP8, ECO:0000269|PubMed:14525949}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DIE2 ALG10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of inward rectifier potassium channel activity|
|dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity|
|regulation of inward rectifier potassium channel activity|
|dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity|
|positive regulation of protein glycosylation|
|regulation of protein glycosylation|
|positive regulation of voltage-gated potassium channel activity|
|dolichol-linked oligosaccharide biosynthetic process|
|oligosaccharide-lipid intermediate biosynthetic process|
|positive regulation of glycoprotein biosynthetic process|
|positive regulation of glycoprotein metabolic process|
|positive regulation of potassium ion transmembrane transporter activity|
|positive regulation of potassium ion transmembrane transport|
|regulation of glycoprotein biosynthetic process|
|positive regulation of potassium ion transport|
|regulation of glycoprotein metabolic process|
|regulation of potassium ion transmembrane transporter activity|
|transferase activity|
|positive regulation of cation channel activity|
|protein N-linked glycosylation|
|regulation of potassium ion transmembrane transport|
|regulation of potassium ion transport|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|positive regulation of cation transmembrane transport|
|positive regulation of ion transmembrane transport|
|regulation of cation channel activity|
|positive regulation of transmembrane transport|
|regulation of ion transmembrane transporter activity|
|macromolecule glycosylation|
|protein glycosylation|
|regulation of transmembrane transporter activity|
|glycosylation|
|positive regulation of ion transport|
|regulation of transporter activity|
|glycoprotein biosynthetic process|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|glycoprotein metabolic process|
|regulation of ion transmembrane transport|
|regulation of transmembrane transport|
|carbohydrate derivative biosynthetic process|
|regulation of ion transport|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|positive regulation of transport|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|positive regulation of protein modification process|
|organonitrogen compound biosynthetic process|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8502
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALG10B Expression in NALM6 Cells: 6.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>