ALG10B

Gene Information

Official Symbol: ALG10B
Official Name: ALG10 alpha-1,2-glucosyltransferase B
Aliases and Previous Symbols: N/A
Entrez ID: 144245
UniProt: Q5I7T1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 (PubMed:14525949). Has a role in maintenance of cochlear outer hair cell function (By similarity). {ECO:0000250|UniProtKB:P50076, ECO:0000250|UniProtKB:Q3UGP8, ECO:0000269|PubMed:14525949}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8502
Expression level (log2 read counts): 6.77

Expression Distribution

positive regulation of inward rectifier potassium channel activity
dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity
regulation of inward rectifier potassium channel activity
dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity
positive regulation of protein glycosylation
regulation of protein glycosylation
positive regulation of voltage-gated potassium channel activity
dolichol-linked oligosaccharide biosynthetic process
oligosaccharide-lipid intermediate biosynthetic process
positive regulation of glycoprotein biosynthetic process
positive regulation of glycoprotein metabolic process
positive regulation of potassium ion transmembrane transporter activity
positive regulation of potassium ion transmembrane transport
regulation of glycoprotein biosynthetic process
positive regulation of potassium ion transport
regulation of glycoprotein metabolic process
regulation of potassium ion transmembrane transporter activity
transferase activity
positive regulation of cation channel activity
protein N-linked glycosylation
regulation of potassium ion transmembrane transport
regulation of potassium ion transport
positive regulation of ion transmembrane transporter activity
positive regulation of transporter activity
positive regulation of cation transmembrane transport
positive regulation of ion transmembrane transport
regulation of cation channel activity
positive regulation of transmembrane transport
regulation of ion transmembrane transporter activity
macromolecule glycosylation
protein glycosylation
regulation of transmembrane transporter activity
glycosylation
positive regulation of ion transport
regulation of transporter activity
glycoprotein biosynthetic process
regulation of cation transmembrane transport
regulation of metal ion transport
glycoprotein metabolic process
regulation of ion transmembrane transport