ALG13 [The Human Chemical-Genetic Interaction Map Project]

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======= ALG13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALG13
  * **<color #00a2e8>Official Name</color>**: ALG13 UDP-N-acetylglucosaminyltransferase subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79868|79868]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NP73|Q9NP73]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALG13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALG13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300776|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco tran 28 C|
|OTU|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity|
|dolichol-linked oligosaccharide biosynthetic process|
|oligosaccharide-lipid intermediate biosynthetic process|
|thiol-dependent ubiquitinyl hydrolase activity|
|protein N-linked glycosylation|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate derivative biosynthetic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|proteolysis|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp114|A-196 10μM R03 exp114]]|-2.9|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-2.69|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-2.56|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-2.17|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.03|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-2|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.92|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.91|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.84|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.83|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.82|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.79|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.78|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.78|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.73|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.73|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.73|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.7|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.81|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.87|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.89|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.89|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.92|
|[[:results:exp539|42°C R08 exp539]]|1.93|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.01|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.03|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.17|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.17|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2.22|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.25|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.47|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmm2|PMM2]]|0.637|
|[[:human genes:g:gmppb|GMPPB]]|0.635|
|[[:human genes:t:thg1l|THG1L]]|0.627|
|[[:human genes:d:dpagt1|DPAGT1]]|0.622|
|[[:human genes:u:uap1|UAP1]]|0.619|
|[[:human genes:g:gfpt1|GFPT1]]|0.609|
|[[:human genes:r:rnmt|RNMT]]|0.608|
|[[:human genes:a:alg1|ALG1]]|0.607|
|[[:human genes:t:triap1|TRIAP1]]|0.59|
|[[:human genes:g:gnb1l|GNB1L]]|0.578|
|[[:human genes:a:atxn10|ATXN10]]|0.571|
|[[:human genes:r:rptor|RPTOR]]|0.565|
|[[:human genes:r:rtcb|RTCB]]|0.564|
|[[:human genes:a:adsl|ADSL]]|0.554|
|[[:human genes:u:uhrf1|UHRF1]]|0.553|
|[[:human genes:t:trnt1|TRNT1]]|0.55|
|[[:human genes:s:srp14|SRP14]]|0.55|
|[[:human genes:e:exoc4|EXOC4]]|0.548|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.544|
|[[:human genes:r:rpp21|RPP21]]|0.54|
|[[:human genes:d:dohh|DOHH]]|0.54|
|[[:human genes:d:dhps|DHPS]]|0.537|
|[[:human genes:m:med16|MED16]]|0.537|
|[[:human genes:v:vezt|VEZT]]|0.536|
|[[:human genes:a:alg2|ALG2]]|0.535|
|[[:human genes:s:slc25a26|SLC25A26]]|0.534|
|[[:human genes:t:tamm41|TAMM41]]|0.533|
|[[:human genes:a:atp5j|ATP5J]]|0.532|
|[[:human genes:t:ten1|TEN1]]|0.525|
|[[:human genes:g:gemin8|GEMIN8]]|0.523|
|[[:human genes:h:haus8|HAUS8]]|0.523|
|[[:human genes:n:nae1|NAE1]]|0.521|
|[[:human genes:e:elac2|ELAC2]]|0.516|
|[[:human genes:t:tsen54|TSEN54]]|0.515|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.514|
|[[:human genes:g:gemin6|GEMIN6]]|0.512|
|[[:human genes:c:chchd4|CHCHD4]]|0.511|
|[[:human genes:p:ppcs|PPCS]]|0.508|
|[[:human genes:t:tti2|TTI2]]|0.506|
|[[:human genes:s:ssb|SSB]]|0.506|
|[[:human genes:r:rpn1|RPN1]]|0.505|
|[[:human genes:t:trmt10a|TRMT10A]]|0.503|
|[[:human genes:y:yars|YARS]]|0.499|
|[[:human genes:a:aars|AARS]]|0.498|
|[[:human genes:g:gemin7|GEMIN7]]|0.497|
|[[:human genes:p:ppa2|PPA2]]|0.496|
|[[:human genes:p:ppp4c|PPP4C]]|0.495|
|[[:human genes:o:osgep|OSGEP]]|0.493|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.493|
|[[:human genes:o:oraov1|ORAOV1]]|0.493|
|[[:human genes:t:taz|TAZ]]|0.49|
|[[:human genes:p:pelo|PELO]]|0.49|
|[[:human genes:o:oip5|OIP5]]|0.488|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.488|
|[[:human genes:m:mtor|MTOR]]|0.487|
|[[:human genes:c:cbfb|CBFB]]|0.484|
|[[:human genes:h:hspd1|HSPD1]]|0.483|
|[[:human genes:r:rpe|RPE]]|0.482|
|[[:human genes:d:dad1|DAD1]]|0.481|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.48|
|[[:human genes:s:sec62|SEC62]]|0.479|
|[[:human genes:a:atp5b|ATP5B]]|0.479|
|[[:human genes:t:telo2|TELO2]]|0.476|
|[[:human genes:s:snf8|SNF8]]|0.475|
|[[:human genes:t:tbca|TBCA]]|0.475|
|[[:human genes:u:ube2g2|UBE2G2]]|0.474|
|[[:human genes:c:c17orf89|C17orf89]]|0.473|
|[[:human genes:b:bap1|BAP1]]|0.472|
|[[:human genes:h:hccs|HCCS]]|0.472|
|[[:human genes:u:utp23|UTP23]]|0.469|
|[[:human genes:t:txnl4b|TXNL4B]]|0.468|
|[[:human genes:d:dr1|DR1]]|0.467|
|[[:human genes:c:crcp|CRCP]]|0.466|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.466|
|[[:human genes:d:dhx29|DHX29]]|0.465|
|[[:human genes:f:fnta|FNTA]]|0.465|
|[[:human genes:q:qars|QARS]]|0.464|
|[[:human genes:m:mllt1|MLLT1]]|0.464|
|[[:human genes:w:wdr24|WDR24]]|0.461|
|[[:human genes:a:alg5|ALG5]]|0.46|
|[[:human genes:t:tprkb|TPRKB]]|0.459|
|[[:human genes:l:lsm10|LSM10]]|0.459|
|[[:human genes:d:ddost|DDOST]]|0.459|
|[[:human genes:h:hars|HARS]]|0.458|
|[[:human genes:c:ccdc101|CCDC101]]|0.457|
|[[:human genes:u:uxt|UXT]]|0.456|
|[[:human genes:g:gpn2|GPN2]]|0.456|
|[[:human genes:t:tgs1|TGS1]]|0.455|
|[[:human genes:l:lsm11|LSM11]]|0.454|
|[[:human genes:e:eny2|ENY2]]|0.454|
|[[:human genes:a:alg6|ALG6]]|0.454|
|[[:human genes:t:tti1|TTI1]]|0.454|
|[[:human genes:d:ddx55|DDX55]]|0.454|
|[[:human genes:r:romo1|ROMO1]]|0.452|
|[[:human genes:b:bcs1l|BCS1L]]|0.45|
|[[:human genes:r:rpia|RPIA]]|0.45|
|[[:human genes:m:mars|MARS]]|0.45|
|[[:human genes:c:cep57|CEP57]]|0.448|
|[[:human genes:d:dhdds|DHDDS]]|0.448|
|[[:human genes:h:hist1h4i|HIST1H4I]]|0.447|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.447|
|[[:human genes:s:sdha|SDHA]]|0.447|
|[[:human genes:c:cct7|CCT7]]|0.446|
|[[:human genes:v:vrk1|VRK1]]|0.445|
|[[:human genes:m:mbtps2|MBTPS2]]|0.444|
|[[:human genes:e:eif4e|EIF4E]]|0.443|
|[[:human genes:r:rft1|RFT1]]|0.442|
|[[:human genes:e:eprs|EPRS]]|0.442|
|[[:human genes:t:thoc6|THOC6]]|0.44|
|[[:human genes:d:dhrsx|DHRSX]]|0.44|
|[[:human genes:n:nars|NARS]]|0.439|
|[[:human genes:s:sars2|SARS2]]|0.439|
|[[:human genes:p:polr3h|POLR3H]]|0.439|
|[[:human genes:e:eif3f|EIF3F]]|0.438|
|[[:human genes:m:med4|MED4]]|0.437|
|[[:human genes:t:tpk1|TPK1]]|0.437|
|[[:human genes:d:ddx20|DDX20]]|0.437|
|[[:human genes:t:tmem41b|TMEM41B]]|0.437|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.436|
|[[:human genes:a:alg8|ALG8]]|0.436|
|[[:human genes:c:cdipt|CDIPT]]|0.435|
|[[:human genes:t:tsen34|TSEN34]]|0.435|
|[[:human genes:k:kdsr|KDSR]]|0.435|
|[[:human genes:a:alg14|ALG14]]|0.435|
|[[:human genes:m:med23|MED23]]|0.432|
|[[:human genes:w:wdr59|WDR59]]|0.432|
|[[:human genes:d:dolk|DOLK]]|0.432|
|[[:human genes:d:dnlz|DNLZ]]|0.431|
|[[:human genes:m:msto1|MSTO1]]|0.431|
|[[:human genes:p:pdss1|PDSS1]]|0.43|
|[[:human genes:t:timm13|TIMM13]]|0.43|
|[[:human genes:s:slc35b1|SLC35B1]]|0.429|
|[[:human genes:s:slc25a19|SLC25A19]]|0.429|
|[[:human genes:n:naa20|NAA20]]|0.427|
|[[:human genes:a:atp5o|ATP5O]]|0.427|
|[[:human genes:t:tbp|TBP]]|0.426|
|[[:human genes:t:tma16|TMA16]]|0.426|
|[[:human genes:t:ttc4|TTC4]]|0.425|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.425|
|[[:human genes:t:tbcb|TBCB]]|0.424|
|[[:human genes:y:yars2|YARS2]]|0.423|
|[[:human genes:m:mrps14|MRPS14]]|0.423|
|[[:human genes:x:xpo5|XPO5]]|0.422|
|[[:human genes:m:mis18a|MIS18A]]|0.422|
|[[:human genes:p:pdcd5|PDCD5]]|0.422|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.421|
|[[:human genes:p:pam16|PAM16]]|0.42|
|[[:human genes:z:znf259|ZNF259]]|0.419|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.418|
|[[:human genes:g:gemin5|GEMIN5]]|0.418|
|[[:human genes:t:thoc3|THOC3]]|0.417|
|[[:human genes:m:mapk14|MAPK14]]|0.417|
|[[:human genes:c:crls1|CRLS1]]|0.417|
|[[:human genes:t:trim28|TRIM28]]|0.416|
|[[:human genes:m:mrps5|MRPS5]]|0.416|
|[[:human genes:s:sec61g|SEC61G]]|0.416|
|[[:human genes:s:srp68|SRP68]]|0.414|
|[[:human genes:p:pggt1b|PGGT1B]]|0.413|
|[[:human genes:n:nbn|NBN]]|0.413|
|[[:human genes:s:snapc5|SNAPC5]]|0.413|
|[[:human genes:v:vps41|VPS41]]|0.413|
|[[:human genes:m:meaf6|MEAF6]]|0.412|
|[[:human genes:z:zrsr2|ZRSR2]]|0.41|
|[[:human genes:w:wdr82|WDR82]]|0.41|
|[[:human genes:u:uqcr10|UQCR10]]|0.41|
|[[:human genes:p:pdpk1|PDPK1]]|0.41|
|[[:human genes:s:srd5a3|SRD5A3]]|0.409|
|[[:human genes:t:tsen2|TSEN2]]|0.408|
|[[:human genes:d:ddx39a|DDX39A]]|0.408|
|[[:human genes:r:rad1|RAD1]]|0.407|
|[[:human genes:n:nsd1|NSD1]]|0.407|
|[[:human genes:a:atp5a1|ATP5A1]]|0.405|
|[[:human genes:e:ercc2|ERCC2]]|0.404|
|[[:human genes:p:polr3b|POLR3B]]|0.403|
|[[:human genes:t:tpi1|TPI1]]|0.402|
|[[:human genes:p:pik3r4|PIK3R4]]|0.402|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.401|
|[[:human genes:s:srp72|SRP72]]|0.401|
|[[:human genes:f:fh|FH]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 660/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|26/26|
|bone|25/25|
|breast|24/30|
|central nervous system|49/49|
|cervix|4/4|
|colorectal|16/17|
|esophagus|11/11|
|fibroblast|1/1|
|gastric|14/14|
|kidney|17/18|
|liver|19/19|
|lung|67/72|
|lymphocyte|12/14|
|ovary|23/25|
|pancreas|22/22|
|peripheral nervous system|15/15|
|plasma cell|11/12|
|prostate|1/1|
|skin|20/20|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|27/28|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4406
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALG13 Expression in NALM6 Cells: 5.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>