ALG13

Gene Information

Official Symbol: ALG13
Official Name: ALG13 UDP-N-acetylglucosaminyltransferase subunit
Aliases and Previous Symbols: N/A
Entrez ID: 79868
UniProt: Q9NP73
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
A-196 10μM R03 exp114	-2.9
CCT251545 20μM R07 exp326	-2.69
Pyronaridine 1μM R06 exp295	-2.56
Tenofovir 10μM R07 exp405	-2.17
Bisphenol F 50μM R08 exp457	-2.03
Doxycycline 10μM R00 exp18	-2
CCCP 1μM R00 exp11	-1.92
UM0125461 0.74μM R02 exp84	-1.91
Lenalidomide 20μM R07 exp375	-1.84
Chlorpromazine 10μM R07 exp344	-1.83
Vinblastine 0.002μM R01 exp60	-1.82
Calcipotriol 5μM R08 exp464	-1.79
Dynasore 10μM R04 exp180	-1.78
Losmapimod 1μM R07 exp376	-1.78
Daidzin 10μM R06 exp280	-1.73
JQ1 0.01μM R03 exp130	-1.73
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.73
SNS-032 15μM R08 exp443	1.7
ETC-159 50μM R08 exp480	1.81
Vitamin-D3 40μM R08 exp536	1.87
DABN racemic mixture R03 exp93	1.89
GSK461364A 0.1μM R03 exp126	1.89
THZ1 0.06μM R08 exp531	1.92
42°C R08 exp539	1.93
TIC10 10μM R08 exp532	2.01
BI-6727 0.04μM R03 exp98	2.03
Aphidicolin 0.4μM R08 exp440	2.17
ONC212 0.15μM R08 exp513	2.17
CFI-400945 25μM R08 exp469	2.22
Tanespimycin 14μM R08 exp527	2.25
GSK-J4 1.5μM R08 exp441	2.47
iCRT14 30μM R08 exp492	2.57

Gene	Correlation
PMM2	0.637
GMPPB	0.635
THG1L	0.627
DPAGT1	0.622
UAP1	0.619
GFPT1	0.609
RNMT	0.608
ALG1	0.607
TRIAP1	0.59
GNB1L	0.578
ATXN10	0.571
RPTOR	0.565
RTCB	0.564
ADSL	0.554
UHRF1	0.553
TRNT1	0.55
SRP14	0.55
EXOC4	0.548
GTF3C3	0.544
RPP21	0.54
DOHH	0.54
DHPS	0.537
MED16	0.537
VEZT	0.536
ALG2	0.535
SLC25A26	0.534
TAMM41	0.533
ATP5J	0.532
TEN1	0.525
GEMIN8	0.523
HAUS8	0.523
NAE1	0.521
ELAC2	0.516
TSEN54	0.515
GTF3C4	0.514
GEMIN6	0.512
CHCHD4	0.511
PPCS	0.508
TTI2	0.506
SSB	0.506
RPN1	0.505
TRMT10A	0.503
YARS	0.499
AARS	0.498
GEMIN7	0.497
PPA2	0.496
PPP4C	0.495
OSGEP	0.493
GTF3C6	0.493
ORAOV1	0.493
TAZ	0.49
PELO	0.49
OIP5	0.488
AASDHPPT	0.488
MTOR	0.487
CBFB	0.484
HSPD1	0.483
RPE	0.482
DAD1	0.481
GTF3C2	0.48
SEC62	0.479
ATP5B	0.479
TELO2	0.476
SNF8	0.475
TBCA	0.475
UBE2G2	0.474
C17orf89	0.473
BAP1	0.472
HCCS	0.472
UTP23	0.469
TXNL4B	0.468
DR1	0.467
CRCP	0.466
SUPV3L1	0.466
DHX29	0.465
FNTA	0.465
QARS	0.464
MLLT1	0.464
WDR24	0.461
ALG5	0.46
TPRKB	0.459
LSM10	0.459
DDOST	0.459
HARS	0.458
CCDC101	0.457
UXT	0.456
GPN2	0.456
TGS1	0.455
LSM11	0.454
ENY2	0.454
ALG6	0.454
TTI1	0.454
DDX55	0.454
ROMO1	0.452
BCS1L	0.45
RPIA	0.45
MARS	0.45
CEP57	0.448
DHDDS	0.448
HIST1H4I	0.447
PPP2R3C	0.447
SDHA	0.447
CCT7	0.446
VRK1	0.445
MBTPS2	0.444
EIF4E	0.443
RFT1	0.442
EPRS	0.442
THOC6	0.44
DHRSX	0.44
NARS	0.439
SARS2	0.439
POLR3H	0.439
EIF3F	0.438
MED4	0.437
TPK1	0.437
DDX20	0.437
TMEM41B	0.437
UQCRC2	0.436
ALG8	0.436
CDIPT	0.435
TSEN34	0.435
KDSR	0.435
ALG14	0.435
MED23	0.432
WDR59	0.432
DOLK	0.432
DNLZ	0.431
MSTO1	0.431
PDSS1	0.43
TIMM13	0.43
SLC35B1	0.429
SLC25A19	0.429
NAA20	0.427
ATP5O	0.427
TBP	0.426
TMA16	0.426
TTC4	0.425
HSD17B10	0.425
TBCB	0.424
YARS2	0.423
MRPS14	0.423
XPO5	0.422
MIS18A	0.422
PDCD5	0.422
KIAA0391	0.421
PAM16	0.42
ZNF259	0.419
GTF2A2	0.418
GEMIN5	0.418
THOC3	0.417
MAPK14	0.417
CRLS1	0.417
TRIM28	0.416
MRPS5	0.416
SEC61G	0.416
SRP68	0.414
PGGT1B	0.413
NBN	0.413
SNAPC5	0.413
VPS41	0.413
MEAF6	0.412
ZRSR2	0.41
WDR82	0.41
UQCR10	0.41
PDPK1	0.41
SRD5A3	0.409
TSEN2	0.408
DDX39A	0.408
RAD1	0.407
NSD1	0.407
ATP5A1	0.405
ERCC2	0.404
POLR3B	0.403
TPI1	0.402
PIK3R4	0.402
RNASEH1	0.401
SRP72	0.401
FH	0.4

Global Fraction of Cell Lines Where Essential: 660/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	26/26
bone	25/25
breast	24/30
central nervous system	49/49
cervix	4/4
colorectal	16/17
esophagus	11/11
fibroblast	1/1
gastric	14/14
kidney	17/18
liver	19/19
lung	67/72
lymphocyte	12/14
ovary	23/25
pancreas	22/22
peripheral nervous system	15/15
plasma cell	11/12
prostate	1/1
skin	20/20
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	27/28
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 4406
Expression level (log2 read counts): 5.39

Expression Distribution

Glyco tran 28 C
OTU

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
dolichol-linked oligosaccharide biosynthetic process
oligosaccharide-lipid intermediate biosynthetic process
thiol-dependent ubiquitinyl hydrolase activity
protein N-linked glycosylation
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate derivative biosynthetic process
endoplasmic reticulum membrane
cellular lipid metabolic process
carbohydrate derivative metabolic process
lipid metabolic process
proteolysis
RNA binding
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process