ALG9 [The Human Chemical-Genetic Interaction Map Project]

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======= ALG9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ALG9
  * **<color #00a2e8>Official Name</color>**: ALG9 alpha-1,2-mannosyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79796|79796]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H6U8|Q9H6U8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ALG9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ALG9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606941|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an alpha-1,2-mannosyltransferase enzyme that functions in lipid-linked oligosaccharide assembly. Mutations in this gene result in congenital disorder of glycosylation type Il. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides. {ECO:0000269|PubMed:15148656, ECO:0000269|PubMed:15945070}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco transf 22|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity|
|dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity|
|alpha-1,2-mannosyltransferase activity|
|dolichol-linked oligosaccharide biosynthetic process|
|oligosaccharide-lipid intermediate biosynthetic process|
|mannosyltransferase activity|
|mannosylation|
|protein N-linked glycosylation|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate derivative biosynthetic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-3.72|
|[[:results:exp453|B02 10μM R08 exp453]]|-3.37|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-2.8|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.72|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.65|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.65|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.6|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.58|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.53|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.5|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-2.43|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.41|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-2.37|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.2|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.13|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.1|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.1|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-2.05|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-2.02|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.97|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.89|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.88|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.81|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.71|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.7|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.73|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.84|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.85|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.86|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.9|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.95|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.96|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.1|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.4|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.79|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dpm3|DPM3]]|0.633|
|[[:human genes:a:alg3|ALG3]]|0.565|
|[[:human genes:m:manf|MANF]]|0.538|
|[[:human genes:d:dpm1|DPM1]]|0.53|
|[[:human genes:s:sec62|SEC62]]|0.524|
|[[:human genes:s:sec63|SEC63]]|0.498|
|[[:human genes:d:dnajc3|DNAJC3]]|0.493|
|[[:human genes:a:alg5|ALG5]]|0.491|
|[[:human genes:u:ube2j1|UBE2J1]]|0.481|
|[[:human genes:m:mpdu1|MPDU1]]|0.468|
|[[:human genes:a:alg6|ALG6]]|0.463|
|[[:human genes:d:derl1|DERL1]]|0.463|
|[[:human genes:d:dnajb11|DNAJB11]]|0.457|
|[[:human genes:d:dpagt1|DPAGT1]]|0.455|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.448|
|[[:human genes:d:dhrsx|DHRSX]]|0.441|
|[[:human genes:a:alg12|ALG12]]|0.44|
|[[:human genes:u:ube2g2|UBE2G2]]|0.425|
|[[:human genes:s:slc33a1|SLC33A1]]|0.414|
|[[:human genes:k:kdsr|KDSR]]|0.409|
|[[:human genes:b:bap1|BAP1]]|0.408|
|[[:human genes:d:dolk|DOLK]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6228
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ALG9 Expression in NALM6 Cells: 5.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>