ALG9

Entrez Summary: This gene encodes an alpha-1,2-mannosyltransferase enzyme that functions in lipid-linked oligosaccharide assembly. Mutations in this gene result in congenital disorder of glycosylation type Il. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]. COMPLETENESS: complete on the 3' end.
UniProt Summary: Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides. {ECO:0000269|PubMed:15148656, ECO:0000269|PubMed:15945070}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bisphenol F 50μM R08 exp457	-3.72
B02 10μM R08 exp453	-3.37
Ethanol 0.003 R08 exp437	-2.8
Bortezomib 0.005μM R00 exp6	-2.72
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.65
THZ531 0.225μM R08 exp444	-2.65
Tubacin 1.6μM R07 exp416	-2.6
Ethanol 0.01 R05 exp234	-2.58
Chloroquine 32μM R08 exp470	-2.53
Thapsigargin 0.005μM R07 exp407	-2.5
Celastrol 0.12μM R05 exp225	-2.43
Dimethyloxaloylglycine 100μM R05 exp229	-2.41
Bisphenol S 100μM R08 exp458	-2.37
TRAIL 50ng/ml R00 exp36	-2.2
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.13
3-Bromopyruvate 7μM R04 exp175	-2.1
Cryptotanshinone 12μM R05 exp227	-2.1
HMS-I2 1μM R06 exp286	-2.05
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-2.02
Trametinib 10μM R02 exp83	-2
Hydroxychloroquine 30μM R08 exp490	-1.97
Aminopterin 0.005μM R07 exp335	-1.89
Benzoate 10000μM R08 exp455	-1.88
proTAME 5μM R04 exp187	-1.81
Cannabidiol 20μM R08 exp466	-1.71
NFN1 0.4μM R03 exp99	-1.7
Hippuristanol 0.12μM R08 exp488	1.73
UM0131023 0.05μM R05 exp248	1.84
Thimerosal 0.85μM R08 exp529	1.85
Aphidicolin 0.4μM R08 exp440	1.86
2-Deoxy-D-glucose 800μM R05 exp214	1.9
iCRT14 30μM R08 exp492	1.95
THZ1 0.06μM R08 exp531	1.96
LY2090314 0.003μM R08 exp500 no dilution day6	2.1
Atovaquone 15μM R08 exp451	2.4
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.79
LY2090314 0.003μM R08 exp499	2.83

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity
dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity
alpha-1,2-mannosyltransferase activity
dolichol-linked oligosaccharide biosynthetic process
oligosaccharide-lipid intermediate biosynthetic process
mannosyltransferase activity
mannosylation
protein N-linked glycosylation
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate derivative biosynthetic process
endoplasmic reticulum membrane
cellular lipid metabolic process
endoplasmic reticulum
carbohydrate derivative metabolic process
lipid metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane