ALKBH4

Entrez Summary: N/A
UniProt Summary: Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation. {ECO:0000269|PubMed:21166655, ECO:0000269|PubMed:23673617}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cleavage furrow ingression
demethylase activity
contractile ring
2-oxoglutarate-dependent dioxygenase activity
oxidative demethylation
protein demethylation
protein dealkylation
cytokinetic process
demethylation
cytoskeleton-dependent cytokinesis
cytokinesis
actomyosin structure organization
oxidoreductase activity
plasma membrane invagination
membrane invagination
midbody
actin binding
cell division
actin cytoskeleton organization
actin filament-based process
membrane organization
oxidation-reduction process
cell cycle process
cytoskeleton organization
cell cycle