ALPK2

Entrez Summary: N/A
UniProt Summary: Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

I-set
Alpha kinase

epicardium morphogenesis
negative regulation of Wnt signaling pathway involved in heart development
regulation of Wnt signaling pathway involved in heart development
cardiac muscle cell development
cardiac cell development
cardiac muscle cell differentiation
cardiocyte differentiation
establishment of cell polarity
striated muscle cell development
muscle cell development
cardiac muscle tissue development
establishment or maintenance of cell polarity
basolateral plasma membrane
striated muscle cell differentiation
negative regulation of Wnt signaling pathway
muscle cell differentiation
heart morphogenesis
striated muscle tissue development
muscle tissue development
regulation of Wnt signaling pathway
protein serine/threonine kinase activity
muscle structure development
heart development
circulatory system development
negative regulation of developmental process
animal organ morphogenesis
protein phosphorylation
negative regulation of multicellular organismal process
negative regulation of signal transduction
phosphorylation
negative regulation of cell communication
negative regulation of signaling
ATP binding
regulation of apoptotic process
regulation of programmed cell death
negative regulation of response to stimulus
cell development
regulation of cell death
tissue development