AMBP
Gene Information
- Official Symbol: AMBP
- Official Name: alpha-1-microglobulin/bikunin precursor
- Aliases and Previous Symbols: N/A
- Entrez ID: 259
- UniProt: P02760
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization. {ECO:0000269|PubMed:7676539}.
Pfam Domains GO Terms
Pfam Domains
| Lipocalin |
| Kunitz BPTI |
GO Terms
| calcium oxalate binding |
| IgA binding |
| porphyrin-containing compound catabolic process |
| pigment catabolic process |
| heme catabolic process |
| tetrapyrrole catabolic process |
| calcium channel inhibitor activity |
| protein-chromophore linkage |
| heme metabolic process |
| negative regulation of JNK cascade |
| porphyrin-containing compound metabolic process |
| negative regulation of stress-activated MAPK cascade |
| negative regulation of stress-activated protein kinase signaling cascade |
| tetrapyrrole metabolic process |
| cofactor catabolic process |
| pigment metabolic process |
| serine-type endopeptidase inhibitor activity |
| heme binding |
| blood microparticle |
| negative regulation of immune response |
| negative regulation of MAPK cascade |
| female pregnancy |
| regulation of JNK cascade |
| multi-multicellular organism process |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| receptor-mediated endocytosis |
| negative regulation of endopeptidase activity |
| negative regulation of peptidase activity |
| negative regulation of proteolysis |
| collagen-containing extracellular matrix |
| negative regulation of protein phosphorylation |
| regulation of endopeptidase activity |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| cofactor metabolic process |
| negative regulation of immune system process |
| aromatic compound catabolic process |
| negative regulation of phosphorylation |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| organic cyclic compound catabolic process |
| negative regulation of intracellular signal transduction |
| endocytosis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| cell surface |
| import into cell |
| protein catabolic process |
| intracellular membrane-bounded organelle |
| viral process |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| symbiotic process |
| negative regulation of catalytic activity |
| interspecies interaction between organisms |
| protein homodimerization activity |
| cell adhesion |
| biological adhesion |
| multi-organism reproductive process |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| negative regulation of cell communication |
| negative regulation of signaling |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of phosphorylation |
| extracellular space |
| negative regulation of response to stimulus |
| regulation of immune system process |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7818
- Expression level (log2 read counts): -3.8
Expression Distribution
AMBP Expression in NALM6 Cells: -3.8
