AMD1 [The Human Chemical-Genetic Interaction Map Project]

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======= AMD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AMD1
  * **<color #00a2e8>Official Name</color>**: adenosylmethionine decarboxylase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=262|262]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17707|P17707]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AMD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AMD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180980|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. {ECO:0000250|UniProtKB:P0DMN7}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM decarbox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|S-adenosylmethioninamine biosynthetic process|
|S-adenosylmethioninamine metabolic process|
|adenosylmethionine decarboxylase activity|
|putrescine binding|
|spermine biosynthetic process|
|spermidine biosynthetic process|
|spermine metabolic process|
|spermidine metabolic process|
|polyamine biosynthetic process|
|polyamine metabolic process|
|S-adenosylmethionine metabolic process|
|cellular biogenic amine biosynthetic process|
|purine nucleoside biosynthetic process|
|purine ribonucleoside biosynthetic process|
|ribonucleoside biosynthetic process|
|amine biosynthetic process|
|nucleoside biosynthetic process|
|glycosyl compound biosynthetic process|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|purine ribonucleoside metabolic process|
|purine nucleoside metabolic process|
|amine metabolic process|
|ribonucleoside metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|glycosyl compound metabolic process|
|purine-containing compound biosynthetic process|
|sulfur compound biosynthetic process|
|ammonium ion metabolic process|
|coenzyme metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|cofactor metabolic process|
|drug metabolic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp134|MS023 2μM R03 exp134]]|1.71|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.73|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.75|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.77|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.8|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.85|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.88|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.91|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.93|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.01|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.16|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.21|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.22|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.43|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.83|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|3.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 19/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1775
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AMD1 Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>