AMD1

Entrez Summary: N/A
UniProt Summary: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. {ECO:0000250|UniProtKB:P0DMN7}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MS023 2μM R03 exp134	1.71
BI-2536 0.001μM R01 exp41	1.73
Fluvastatin 2.2μM R06 exp282	1.75
Betulinic acid 10 to 15μM on day4 R05 exp222	1.77
Chloramphenicol 20μM R00 exp13	1.8
LY2090314 0.003μM R08 exp500 no dilution day6	1.85
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.88
MK-1775 0.32μM R02 exp75	1.91
Genistein 15μM R07 exp360	1.93
Ammonium tetrathiomolybdate 10μM R08 exp448	2.01
Clomiphene 4.4μM R02 exp68	2.16
Vemurafenib 6.6μM R08 exp434	2.21
BI-D1870 3.15μM R02 exp66	2.22
WYE-354 6μM R02 exp90	2.43
Oligomycin-A 2μM R00 exp25	2.83
Calcium Ionophore 0.4μM R07 exp342	3.57

Global Fraction of Cell Lines Where Essential: 19/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	1/20
lung	1/75
lymphocyte	1/16
ovary	1/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	3/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

S-adenosylmethioninamine biosynthetic process
S-adenosylmethioninamine metabolic process
adenosylmethionine decarboxylase activity
putrescine binding
spermine biosynthetic process
spermidine biosynthetic process
spermine metabolic process
spermidine metabolic process
polyamine biosynthetic process
polyamine metabolic process
S-adenosylmethionine metabolic process
cellular biogenic amine biosynthetic process
purine nucleoside biosynthetic process
purine ribonucleoside biosynthetic process
ribonucleoside biosynthetic process
amine biosynthetic process
nucleoside biosynthetic process
glycosyl compound biosynthetic process
cellular biogenic amine metabolic process
cellular amine metabolic process
purine ribonucleoside metabolic process
purine nucleoside metabolic process
amine metabolic process
ribonucleoside metabolic process
nucleobase-containing small molecule biosynthetic process
nucleoside metabolic process
glycosyl compound metabolic process
purine-containing compound biosynthetic process
sulfur compound biosynthetic process
ammonium ion metabolic process
coenzyme metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process
cofactor metabolic process
drug metabolic process
nucleobase-containing small molecule metabolic process
small molecule biosynthetic process
carbohydrate derivative biosynthetic process
carbohydrate derivative metabolic process
nucleobase-containing compound biosynthetic process