AMFR [The Human Chemical-Genetic Interaction Map Project]

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======= AMFR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AMFR
  * **<color #00a2e8>Official Name</color>**: autocrine motility factor receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=267|267]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKV5|Q9UKV5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AMFR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AMFR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603243|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
|zf-rbx1|
|CUE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|BAT3 complex binding|
|Derlin-1 retrotranslocation complex|
|ubiquitin-ubiquitin ligase activity|
|endoplasmic reticulum mannose trimming|
|ubiquitin-specific protease binding|
|protein alpha-1,2-demannosylation|
|protein demannosylation|
|endoplasmic reticulum quality control compartment|
|protein deglycosylation|
|protein K48-linked ubiquitination|
|protein autoubiquitination|
|ubiquitin-dependent ERAD pathway|
|protein binding, bridging|
|ERAD pathway|
|positive regulation of protein binding|
|chaperone binding|
|endoplasmic reticulum unfolded protein response|
|ubiquitin ligase complex|
|integral component of endoplasmic reticulum membrane|
|cellular response to unfolded protein|
|growth cone|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|positive regulation of binding|
|response to topologically incorrect protein|
|signaling receptor activity|
|regulation of protein binding|
|ubiquitin protein ligase activity|
|protein folding|
|ubiquitin-protein transferase activity|
|response to endoplasmic reticulum stress|
|learning or memory|
|aging|
|protein polyubiquitination|
|cognition|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|neuronal cell body|
|regulation of binding|
|glycoprotein metabolic process|
|dendrite|
|protein complex oligomerization|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|behavior|
|proteolysis involved in cellular protein catabolic process|
|protein-containing complex|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|perinuclear region of cytoplasm|
|protein modification by small protein conjugation|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|protein modification by small protein conjugation or removal|
|response to organonitrogen compound|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|response to nitrogen compound|
|proteolysis|
|nervous system process|
|protein-containing complex assembly|
|cellular response to stress|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|protein-containing complex subunit organization|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.03|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.81|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.7|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.75|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.85|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.86|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.02|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.06|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.07|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga2|GOLGA2]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7393
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AMFR Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>