AMFR

Entrez Summary: This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R02 exp89	-2.03
BI-2536 0.02μM R03 exp96	-1.81
Golgicide-A 2μM R03 exp121	1.7
THZ531 0.225μM R08 exp444	1.75
Tunicamycin 0.04μM R07 exp418	1.85
Hypoxia 5%O2 R04 exp191	1.86
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.02
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.06
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.07
CCT251545 20μM R07 exp326	2.08

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

BAT3 complex binding
Derlin-1 retrotranslocation complex
ubiquitin-ubiquitin ligase activity
endoplasmic reticulum mannose trimming
ubiquitin-specific protease binding
protein alpha-1,2-demannosylation
protein demannosylation
endoplasmic reticulum quality control compartment
protein deglycosylation
protein K48-linked ubiquitination
protein autoubiquitination
ubiquitin-dependent ERAD pathway
protein binding, bridging
ERAD pathway
positive regulation of protein binding
chaperone binding
endoplasmic reticulum unfolded protein response
ubiquitin ligase complex
integral component of endoplasmic reticulum membrane
cellular response to unfolded protein
growth cone
cellular response to topologically incorrect protein
response to unfolded protein
positive regulation of binding
response to topologically incorrect protein
signaling receptor activity
regulation of protein binding
ubiquitin protein ligase activity
protein folding
ubiquitin-protein transferase activity
response to endoplasmic reticulum stress
learning or memory
aging
protein polyubiquitination
cognition
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
neuronal cell body
regulation of binding
glycoprotein metabolic process