AMIGO1

Gene Information

Official Symbol: AMIGO1
Official Name: adhesion molecule with Ig like domain 1
Aliases and Previous Symbols: N/A
Entrez ID: 57463
UniProt: Q86WK6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:Q80ZD7, ECO:0000250|UniProtKB:Q80ZD8}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8008
Expression level (log2 read counts): 1.0

Expression Distribution

Screen	Score
Amiloride 100μM R08 exp447	-1.71
Cisplatin 0.35μM R06 exp273	1.79
Lead acetate 990μM R08 exp496	2.48

LRR 4
I-set
V-set

pericellular basket
cellular response to L-glutamate
response to L-glutamate
positive regulation of voltage-gated potassium channel activity
axonal fasciculation
neuron projection fasciculation
positive regulation of potassium ion transmembrane transporter activity
neuronal cell body membrane
positive regulation of potassium ion transmembrane transport
potassium channel regulator activity
positive regulation of potassium ion transport
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
neuron recognition
regulation of potassium ion transmembrane transporter activity
positive regulation of synapse assembly
cellular response to nutrient
cellular response to amino acid stimulus
positive regulation of cation channel activity
regulation of potassium ion transmembrane transport
voltage-gated potassium channel complex
positive regulation of axonogenesis
regulation of potassium ion transport
positive regulation of ion transmembrane transporter activity
regulation of synapse assembly
myelination
axon ensheathment
ensheathment of neurons
positive regulation of transporter activity
response to amino acid
perikaryon
positive regulation of cation transmembrane transport
positive regulation of ion transmembrane transport
positive regulation of cell morphogenesis involved in differentiation
homophilic cell adhesion via plasma membrane adhesion molecules
regulation of cation channel activity
regulation of axonogenesis
positive regulation of transmembrane transport
cellular response to acid chemical
response to nutrient
regulation of synapse organization