AMN

Entrez Summary: The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008].
UniProt Summary: Necessary for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052). Required for normal CUBN- mediated protein transport in the kidney. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity). {ECO:0000250|UniProtKB:Q99JB7, ECO:0000269|PubMed:14576052, ECO:0000305|PubMed:12590260}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.97
Nutlin-3A 1.6μM R06 exp294	2.38

cobalamin transport
high-density lipoprotein particle clearance
cobalamin metabolic process
Golgi to plasma membrane protein transport
vitamin transport
plasma lipoprotein particle clearance
excretion
cofactor transport
establishment of protein localization to plasma membrane
brush border membrane
clathrin-coated pit
endocytic vesicle
tetrapyrrole metabolic process
Golgi to plasma membrane transport
regulation of plasma lipoprotein particle levels
water-soluble vitamin metabolic process
vesicle-mediated transport to the plasma membrane
post-Golgi vesicle-mediated transport
vitamin metabolic process
drug transport
protein localization to plasma membrane
endosome membrane
protein localization to cell periphery
receptor-mediated endocytosis
establishment of protein localization to membrane
apical plasma membrane
signaling receptor binding
Golgi vesicle transport
cofactor metabolic process
protein localization to membrane
drug metabolic process
endocytosis
protein-containing complex
import into cell
response to drug
protein transport
peptide transport
amide transport
cellular protein localization
extracellular space