AMOTL1 [The Human Chemical-Genetic Interaction Map Project]

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======= AMOTL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AMOTL1
  * **<color #00a2e8>Official Name</color>**: angiomotin like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=154810|154810]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IY63|Q8IY63]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AMOTL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AMOTL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614657|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Angiomotin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment of cell polarity involved in ameboidal cell migration|
|hippo signaling|
|COP9 signalosome|
|positive regulation of blood vessel endothelial cell migration|
|regulation of blood vessel endothelial cell migration|
|positive regulation of endothelial cell migration|
|establishment of cell polarity|
|bicellular tight junction|
|positive regulation of epithelial cell migration|
|regulation of endothelial cell migration|
|ameboidal-type cell migration|
|lamellipodium|
|establishment or maintenance of cell polarity|
|regulation of epithelial cell migration|
|cytoplasmic vesicle|
|angiogenesis|
|apical plasma membrane|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|blood vessel morphogenesis|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|blood vessel development|
|actin cytoskeleton organization|
|positive regulation of cell migration|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|actin filament-based process|
|tube morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|identical protein binding|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|cell-cell signaling|
|locomotion|
|movement of cell or subcellular component|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.75|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|1.77|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10663
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AMOTL1 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>