AMOTL1

Entrez Summary: N/A
UniProt Summary: Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

establishment of cell polarity involved in ameboidal cell migration
hippo signaling
COP9 signalosome
positive regulation of blood vessel endothelial cell migration
regulation of blood vessel endothelial cell migration
positive regulation of endothelial cell migration
establishment of cell polarity
bicellular tight junction
positive regulation of epithelial cell migration
regulation of endothelial cell migration
ameboidal-type cell migration
lamellipodium
establishment or maintenance of cell polarity
regulation of epithelial cell migration
cytoplasmic vesicle
angiogenesis
apical plasma membrane
cell-cell signaling by wnt
Wnt signaling pathway
blood vessel morphogenesis
cell surface receptor signaling pathway involved in cell-cell signaling
blood vessel development
actin cytoskeleton organization
positive regulation of cell migration
vasculature development
cardiovascular system development
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
actin filament-based process
tube morphogenesis
tube development
regulation of cell migration
circulatory system development
anatomical structure formation involved in morphogenesis
regulation of cell motility
cell migration
regulation of locomotion
regulation of cellular component movement
identical protein binding