AMT [The Human Chemical-Genetic Interaction Map Project]

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======= AMT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AMT
  * **<color #00a2e8>Official Name</color>**: aminomethyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=275|275]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48728|P48728]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AMT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AMT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/238310|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of four critical components of the glycine cleavage system. Mutations in this gene have been associated with glycine encephalopathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The glycine cleavage system catalyzes the degradation of glycine. {ECO:0000269|PubMed:16051266}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GCV T|
|GCV T C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aminomethyltransferase activity|
|glycine decarboxylation via glycine cleavage system|
|glycine catabolic process|
|transaminase activity|
|serine family amino acid catabolic process|
|glycine metabolic process|
|neurotransmitter catabolic process|
|serine family amino acid metabolic process|
|neurotransmitter metabolic process|
|alpha-amino acid catabolic process|
|cellular amino acid catabolic process|
|drug catabolic process|
|alpha-amino acid metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|cellular amino acid metabolic process|
|methylation|
|regulation of neurotransmitter levels|
|mitochondrial matrix|
|small molecule catabolic process|
|drug metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|mitochondrion|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13943
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AMT Expression in NALM6 Cells: 2.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>