AMT

Entrez Summary: This gene encodes one of four critical components of the glycine cleavage system. Mutations in this gene have been associated with glycine encephalopathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
UniProt Summary: The glycine cleavage system catalyzes the degradation of glycine. {ECO:0000269|PubMed:16051266}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GCV T
GCV T C

aminomethyltransferase activity
glycine decarboxylation via glycine cleavage system
glycine catabolic process
transaminase activity
serine family amino acid catabolic process
glycine metabolic process
neurotransmitter catabolic process
serine family amino acid metabolic process
neurotransmitter metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
drug catabolic process
alpha-amino acid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
cellular amino acid metabolic process
methylation
regulation of neurotransmitter levels
mitochondrial matrix
small molecule catabolic process
drug metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
mitochondrion
small molecule metabolic process
organic substance catabolic process
cellular catabolic process