ANAPC15 [The Human Chemical-Genetic Interaction Map Project]

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======= ANAPC15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANAPC15
  * **<color #00a2e8>Official Name</color>**: anaphase promoting complex subunit 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25906|25906]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60006|P60006]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANAPC15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANAPC15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614717|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20. {ECO:0000269|PubMed:21926987}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of spindle checkpoint|
|regulation of mitotic spindle checkpoint|
|regulation of mitotic cell cycle spindle assembly checkpoint|
|anaphase-promoting complex|
|regulation of cell cycle checkpoint|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|regulation of sister chromatid segregation|
|anaphase-promoting complex-dependent catabolic process|
|intracellular|
|regulation of chromosome segregation|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|regulation of chromosome organization|
|proteasomal protein catabolic process|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|protein catabolic process|
|regulation of cell cycle process|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of cell cycle|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-3.5|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.77|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.6|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.56|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.42|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.36|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.34|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-2.28|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-2.27|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.26|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.22|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.19|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-2.16|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.15|
|[[:results:exp275|Citral 75μM R06 exp275]]|-2.09|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.05|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.04|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.99|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.98|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.94|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.93|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.92|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.85|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.85|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.82|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.73|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.7|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:anapc13|ANAPC13]]|0.431|
|[[:human genes:u:ube2c|UBE2C]]|0.43|
|[[:human genes:s:sgol1|SGOL1]]|0.424|
|[[:human genes:u:ube2s|UBE2S]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 180/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|5/28|
|blood|10/28|
|bone|11/26|
|breast|10/33|
|central nervous system|13/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|2/16|
|kidney|7/21|
|liver|6/20|
|lung|28/75|
|lymphocyte|6/16|
|ovary|8/26|
|pancreas|4/24|
|peripheral nervous system|2/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|6/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3163
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANAPC15 Expression in NALM6 Cells: 5.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>