ANAPC15

Entrez Summary: N/A
UniProt Summary: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20. {ECO:0000269|PubMed:21926987}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Apcin 25μM plus proTAME 2μM R04 exp177	-3.5
Radicicol 0.16μM R05 exp242	-2.77
Arsenate 40μM R06 exp264	-2.6
Demecolcine 0.03μM R05 exp228	-2.56
HMS-I2 10μM R06 exp288	-2.42
UMK57 1μM R01 exp59	-2.36
proTAME 5μM R04 exp187	-2.34
Adefovir 20μM R07 exp332	-2.28
Apcin 50 to 100μM on day4 R04 exp176	-2.27
Centrinone 0.5μM R07 exp343	-2.26
Colchicine 0.009μM R05 exp215	-2.22
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.19
Campthothecin 0.001μM R06 exp270	-2.16
Etoposide 0.1μM R05 exp198	-2.15
Citral 75μM R06 exp275	-2.09
BI-6727 0.0125μM R03 exp97	-2.05
LY2090314 0.003μM R08 exp500 no dilution day6	-2.04
Menadione 5μM R06 exp292	-1.99
Vinblastine 0.002μM R01 exp60	-1.98
LB-100 4.1μM R02 exp72	-1.94
Talazoparib 0.006μM R06 exp299	-1.93
CCT251545 0.2μM R06 exp271	-1.92
Citral 50μM R06 exp274	-1.85
LLY-284 2.6μM R06 exp291	-1.85
Rucaparib 6.5μM R08 exp520	-1.82
Aphidicolin 0.4μM R08 exp440	-1.73
RO-3306 3 to 4μM on day4 R04 exp165	-1.7
Nicotinamide 1000μM R03 exp101	1.8

Global Fraction of Cell Lines Where Essential: 180/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	5/28
blood	10/28
bone	11/26
breast	10/33
central nervous system	13/56
cervix	1/4
colorectal	1/17
esophagus	4/13
fibroblast	1/1
gastric	2/16
kidney	7/21
liver	6/20
lung	28/75
lymphocyte	6/16
ovary	8/26
pancreas	4/24
peripheral nervous system	2/16
plasma cell	3/15
prostate	0/1
skin	4/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	5/22
urinary tract	6/29
uterus	3/5

Expression Distribution

regulation of spindle checkpoint
regulation of mitotic spindle checkpoint
regulation of mitotic cell cycle spindle assembly checkpoint
anaphase-promoting complex
regulation of cell cycle checkpoint
regulation of mitotic metaphase/anaphase transition
regulation of metaphase/anaphase transition of cell cycle
regulation of mitotic sister chromatid separation
regulation of chromosome separation
regulation of mitotic sister chromatid segregation
regulation of sister chromatid segregation
anaphase-promoting complex-dependent catabolic process
intracellular
regulation of chromosome segregation
regulation of mitotic nuclear division
regulation of nuclear division
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of chromosome organization
proteasomal protein catabolic process
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
cell division
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
regulation of mitotic cell cycle
protein catabolic process
regulation of cell cycle process
cellular macromolecule catabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
regulation of cell cycle
proteolysis
regulation of organelle organization
cell cycle
organic substance catabolic process
cellular catabolic process