ANKH [The Human Chemical-Genetic Interaction Map Project]

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======= ANKH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANKH
  * **<color #00a2e8>Official Name</color>**: ANKH inorganic pyrophosphate transport regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56172|56172]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCJ1|Q9HCJ1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANKH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANKH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605145|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ANKH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inorganic diphosphate transmembrane transporter activity|
|outer membrane|
|phosphate ion transmembrane transporter activity|
|inorganic diphosphate transport|
|inorganic phosphate transmembrane transporter activity|
|phosphate ion transmembrane transport|
|phosphate ion transport|
|regulation of bone mineralization|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|inorganic anion transmembrane transport|
|inorganic anion transport|
|regulation of ossification|
|locomotory behavior|
|anion transmembrane transport|
|skeletal system development|
|behavior|
|anion transport|
|inorganic ion transmembrane transport|
|ion transmembrane transport|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.59|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.57|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.38|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.28|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.09|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.03|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.79|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.12|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.48|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cyb561a3|CYB561A3]]|0.536|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.461|
|[[:human genes:i:ireb2|IREB2]]|0.429|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2214
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANKH Expression in NALM6 Cells: 6.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>