ANKH

Gene Information
  • Official Symbol: ANKH
  • Official Name: ANKH inorganic pyrophosphate transport regulator
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 56172
  • UniProt: Q9HCJ1
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia. [provided by RefSeq, Jul 2008].
  • UniProt Summary: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 2214
  • Expression level (log2 read counts): 6.21

Expression Distribution

  • Last modified: 2026/01/07 22:36
  • by 127.0.0.1