ANKIB1

Gene Information

Official Symbol: ANKIB1
Official Name: ankyrin repeat and IBR domain containing 1
Aliases and Previous Symbols: N/A
Entrez ID: 54467
UniProt: Q9P2G1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin- conjugating enzymes and then transfers it to substrates. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17270
Expression level (log2 read counts): 6.26

Expression Distribution

Ank
Ank 2
IBR

ubiquitin conjugating enzyme binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
ubiquitin ligase complex
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
positive regulation of protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
ubiquitin protein ligase activity
regulation of cellular protein catabolic process
protein polyubiquitination
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
positive regulation of catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
regulation of proteolysis
protein modification by small protein conjugation
regulation of cellular catabolic process
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
regulation of catabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
organic substance catabolic process
cellular catabolic process