ANKLE1 [The Human Chemical-Genetic Interaction Map Project]

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======= ANKLE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANKLE1
  * **<color #00a2e8>Official Name</color>**: ankyrin repeat and LEM domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=126549|126549]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NAG6|Q8NAG6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANKLE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANKLE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619348|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Endonuclease that probably plays a role in the DNA damage response and DNA repair. {ECO:0000269|PubMed:22399800, ECO:0000269|PubMed:27245214}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank|
|Ank 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endonuclease activity|
|positive regulation of response to DNA damage stimulus|
|protein export from nucleus|
|nuclear export|
|regulation of response to DNA damage stimulus|
|nucleocytoplasmic transport|
|nuclear transport|
|nucleic acid phosphodiester bond hydrolysis|
|DNA repair|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|intracellular protein transport|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.81|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.73|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.93|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.01|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.565|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.516|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.497|
|[[:human genes:c:chd4|CHD4]]|0.496|
|[[:human genes:o:orc6|ORC6]]|0.495|
|[[:human genes:d:dock6|DOCK6]]|0.494|
|[[:human genes:t:tfip11|TFIP11]]|0.491|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.486|
|[[:human genes:t:twistnb|TWISTNB]]|0.485|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.485|
|[[:human genes:g:gprin2|GPRIN2]]|0.483|
|[[:human genes:t:tspy8|TSPY8]]|0.481|
|[[:human genes:p:psma6|PSMA6]]|0.48|
|[[:human genes:e:exosc9|EXOSC9]]|0.479|
|[[:human genes:d:ddtl|DDTL]]|0.479|
|[[:human genes:p:polr2d|POLR2D]]|0.478|
|[[:human genes:z:zfand5|ZFAND5]]|0.477|
|[[:human genes:m:mt1e|MT1E]]|0.476|
|[[:human genes:r:rpl9|RPL9]]|0.474|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.472|
|[[:human genes:r:rrn3|RRN3]]|0.472|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.471|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.471|
|[[:human genes:u:utp3|UTP3]]|0.469|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.468|
|[[:human genes:o:orc1|ORC1]]|0.468|
|[[:human genes:p:psmb4|PSMB4]]|0.467|
|[[:human genes:i:ik|IK]]|0.466|
|[[:human genes:s:slc4a1|SLC4A1]]|0.465|
|[[:human genes:z:znf541|ZNF541]]|0.463|
|[[:human genes:h:hivep3|HIVEP3]]|0.462|
|[[:human genes:v:vasn|VASN]]|0.461|
|[[:human genes:r:rfxank|RFXANK]]|0.459|
|[[:human genes:c:cactin|CACTIN]]|0.459|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.456|
|[[:human genes:f:fam25b|FAM25B]]|0.455|
|[[:human genes:a:acsf2|ACSF2]]|0.453|
|[[:human genes:d:dtl|DTL]]|0.452|
|[[:human genes:t:tceb3c|TCEB3C]]|0.452|
|[[:human genes:g:gid4|GID4]]|0.451|
|[[:human genes:o:ogfr|OGFR]]|0.451|
|[[:human genes:n:narfl|NARFL]]|0.451|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.45|
|[[:human genes:g:gar1|GAR1]]|0.45|
|[[:human genes:f:fam160a1|FAM160A1]]|0.449|
|[[:human genes:k:kctd17|KCTD17]]|0.446|
|[[:human genes:l:loc643669|LOC643669]]|0.444|
|[[:human genes:r:ranbp2|RANBP2]]|0.443|
|[[:human genes:a:aamp|AAMP]]|0.443|
|[[:human genes:r:rpl34|RPL34]]|0.442|
|[[:human genes:p:psmc2|PSMC2]]|0.441|
|[[:human genes:a:akirin2|AKIRIN2]]|0.441|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.44|
|[[:human genes:d:disp2|DISP2]]|0.44|
|[[:human genes:n:nsf|NSF]]|0.44|
|[[:human genes:t:tspy2|TSPY2]]|0.437|
|[[:human genes:s:smg1|SMG1]]|0.437|
|[[:human genes:c:col2a1|COL2A1]]|0.436|
|[[:human genes:l:lrr1|LRR1]]|0.436|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.435|
|[[:human genes:i:igfn1|IGFN1]]|0.434|
|[[:human genes:s:s1pr4|S1PR4]]|0.434|
|[[:human genes:c:chaf1a|CHAF1A]]|0.434|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.433|
|[[:human genes:n:nup43|NUP43]]|0.433|
|[[:human genes:p:psmd3|PSMD3]]|0.433|
|[[:human genes:k:krt78|KRT78]]|0.433|
|[[:human genes:z:znf106|ZNF106]]|0.432|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.432|
|[[:human genes:s:syt9|SYT9]]|0.432|
|[[:human genes:c:cbwd3|CBWD3]]|0.432|
|[[:human genes:a:aatf|AATF]]|0.432|
|[[:human genes:t:tyms|TYMS]]|0.43|
|[[:human genes:r:rps12|RPS12]]|0.429|
|[[:human genes:c:ccna2|CCNA2]]|0.427|
|[[:human genes:g:gosr2|GOSR2]]|0.427|
|[[:human genes:t:ticrr|TICRR]]|0.427|
|[[:human genes:r:rad51|RAD51]]|0.425|
|[[:human genes:a:atxn1|ATXN1]]|0.425|
|[[:human genes:p:psmb1|PSMB1]]|0.425|
|[[:human genes:s:smg7|SMG7]]|0.423|
|[[:human genes:a:aqr|AQR]]|0.423|
|[[:human genes:k:krt2|KRT2]]|0.422|
|[[:human genes:u:upf1|UPF1]]|0.421|
|[[:human genes:r:rps2|RPS2]]|0.421|
|[[:human genes:r:rrp7a|RRP7A]]|0.421|
|[[:human genes:s:slc6a17|SLC6A17]]|0.42|
|[[:human genes:s:ssh2|SSH2]]|0.42|
|[[:human genes:e:elmod3|ELMOD3]]|0.419|
|[[:human genes:p:pcf11|PCF11]]|0.419|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.418|
|[[:human genes:c:chmp4b|CHMP4B]]|0.418|
|[[:human genes:m:mcoln1|MCOLN1]]|0.418|
|[[:human genes:r:rpl35|RPL35]]|0.417|
|[[:human genes:s:supt5h|SUPT5H]]|0.417|
|[[:human genes:d:dhx38|DHX38]]|0.417|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.417|
|[[:human genes:x:xab2|XAB2]]|0.417|
|[[:human genes:a:atp1a3|ATP1A3]]|0.417|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.417|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.417|
|[[:human genes:c:c14orf93|C14orf93]]|0.417|
|[[:human genes:t:tonsl|TONSL]]|0.416|
|[[:human genes:m:mylk3|MYLK3]]|0.415|
|[[:human genes:r:rffl|RFFL]]|0.415|
|[[:human genes:w:wdr87|WDR87]]|0.414|
|[[:human genes:s:sorcs3|SORCS3]]|0.414|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.413|
|[[:human genes:h:hinfp|HINFP]]|0.412|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.411|
|[[:human genes:u:utp18|UTP18]]|0.411|
|[[:human genes:s:shpk|SHPK]]|0.41|
|[[:human genes:m:myo1h|MYO1H]]|0.41|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.41|
|[[:human genes:c:ccdc116|CCDC116]]|0.409|
|[[:human genes:n:nupl1|NUPL1]]|0.409|
|[[:human genes:c:cbwd5|CBWD5]]|0.409|
|[[:human genes:p:polr2j3|POLR2J3]]|0.408|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.407|
|[[:human genes:u:ubap1|UBAP1]]|0.407|
|[[:human genes:s:scaf1|SCAF1]]|0.407|
|[[:human genes:p:psmd11|PSMD11]]|0.406|
|[[:human genes:k:kif3c|KIF3C]]|0.406|
|[[:human genes:z:znf655|ZNF655]]|0.405|
|[[:human genes:s:srgap2c|SRGAP2C]]|0.405|
|[[:human genes:r:rplp1|RPLP1]]|0.405|
|[[:human genes:v:vps54|VPS54]]|0.404|
|[[:human genes:c:cdc45|CDC45]]|0.404|
|[[:human genes:a:akap1|AKAP1]]|0.404|
|[[:human genes:e:exosc6|EXOSC6]]|0.402|
|[[:human genes:r:rps19|RPS19]]|0.401|
|[[:human genes:a:add2|ADD2]]|0.401|
|[[:human genes:n:nipbl|NIPBL]]|0.401|
|[[:human genes:r:rpl6|RPL6]]|0.401|
|[[:human genes:s:slc5a5|SLC5A5]]|0.401|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.4|
|[[:human genes:c:cdh24|CDH24]]|0.4|
|[[:human genes:r:rpl30|RPL30]]|0.4|
|[[:human genes:p:pan3|PAN3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1926
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANKLE1 Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>