ANKLE1

Entrez Summary: N/A
UniProt Summary: Endonuclease that probably plays a role in the DNA damage response and DNA repair. {ECO:0000269|PubMed:22399800, ECO:0000269|PubMed:27245214}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.81
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.73
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.93
UM131593 0.1μM R01 exp58	2.01
Q15 1 to 2μM on day4 R04 exp164	2.05

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ank
Ank 2

endonuclease activity
positive regulation of response to DNA damage stimulus
protein export from nucleus
nuclear export
regulation of response to DNA damage stimulus
nucleocytoplasmic transport
nuclear transport
nucleic acid phosphodiester bond hydrolysis
DNA repair
regulation of cellular response to stress
DNA metabolic process
cellular response to DNA damage stimulus
intracellular protein transport
regulation of response to stress
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
cellular response to stress
establishment of localization in cell
nitrogen compound transport