ANKRD17 [The Human Chemical-Genetic Interaction Map Project]

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======= ANKRD17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANKRD17
  * **<color #00a2e8>Official Name</color>**: ankyrin repeat domain 17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26057|26057]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75179|O75179]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANKRD17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANKRD17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615929|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KH 1|
|Ank 2|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of MDA-5 signaling pathway|
|regulation of MDA-5 signaling pathway|
|blood vessel maturation|
|positive regulation of RIG-I signaling pathway|
|negative regulation of smooth muscle cell differentiation|
|regulation of RIG-I signaling pathway|
|regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|regulation of smooth muscle cell differentiation|
|positive regulation of G1/S transition of mitotic cell cycle|
|positive regulation of cell cycle G1/S phase transition|
|negative regulation of muscle cell differentiation|
|regulation of defense response to virus|
|positive regulation of mitotic cell cycle phase transition|
|positive regulation of cell cycle phase transition|
|regulation of DNA replication|
|chromatin|
|anatomical structure maturation|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|regulation of muscle cell differentiation|
|regulation of cell cycle G1/S phase transition|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of immune effector process|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|nuclear membrane|
|developmental maturation|
|positive regulation of cell cycle process|
|defense response to bacterium|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|positive regulation of cell cycle|
|chromatin binding|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|positive regulation of cytokine production|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|blood vessel development|
|positive regulation of multi-organism process|
|vasculature development|
|cardiovascular system development|
|regulation of response to biotic stimulus|
|positive regulation of response to external stimulus|
|regulation of mitotic cell cycle|
|response to bacterium|
|regulation of cytokine production|
|viral process|
|negative regulation of cell differentiation|
|regulation of cell cycle process|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|positive regulation of immune response|
|circulatory system development|
|negative regulation of developmental process|
|defense response to other organism|
|positive regulation of intracellular signal transduction|
|regulation of response to external stimulus|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of cell cycle|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|regulation of response to stress|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.54|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.49|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.31|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.31|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.21|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.1|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.05|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.99|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.94|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.91|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.83|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.83|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.81|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.79|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.72|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.72|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.88|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.88|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.48|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.52|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.63|
|[[:results:exp504|MK2206 4μM R08 exp504]]|3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:ankhd1|ANKHD1]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6095
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANKRD17 Expression in NALM6 Cells: 7.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>