ANKRD17

Gene Information

Official Symbol: ANKRD17
Official Name: ankyrin repeat domain 17
Aliases and Previous Symbols: N/A
Entrez ID: 26057
UniProt: O75179
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vinblastine 0.015μM R05 exp208	-2.54
Quercetin 20μM R08 exp517	-2.49
Parthenolide 2.5μM R05 exp238	-2.31
S-trityl-L-cysteine 0.5μM R05 exp243	-2.31
GSK591 2.6μM R03 exp128	-2.21
Mdivi-1 15μM R05 exp217	-2.1
Colchicine 0.009μM R05 exp215	-2.05
Tubacin 1.6μM R07 exp416	-1.99
Cytochalasin-B 5μM R07 exp349	-1.94
B02 10μM R08 exp453	-1.91
BML-284 0.09μM R08 exp460	-1.83
Thimerosal 0.85μM R08 exp529	-1.83
RO-3307 4.7μM R02 exp80	-1.81
Sulforaphane 9μM R08 exp525	-1.79
Dexamethasone 0.006μM R07 exp351	1.72
Doxorubicin 0.02μM R08 exp478	1.72
Aminopterin 0.005μM R07 exp335	1.88
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.88
Olaparib 4μM R08 exp512	2.48
Cerivastatin 0.15μM R05 exp226	2.52
Golgicide-A 4μM R03 exp122	2.63
MK2206 4μM R08 exp504	3

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	1/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6095
Expression level (log2 read counts): 7.77

Expression Distribution

KH 1
Ank 2
Ank

positive regulation of MDA-5 signaling pathway
regulation of MDA-5 signaling pathway
blood vessel maturation
positive regulation of RIG-I signaling pathway
negative regulation of smooth muscle cell differentiation
regulation of RIG-I signaling pathway
regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
regulation of smooth muscle cell differentiation
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of cell cycle G1/S phase transition
negative regulation of muscle cell differentiation
regulation of defense response to virus
positive regulation of mitotic cell cycle phase transition
positive regulation of cell cycle phase transition
regulation of DNA replication
chromatin
anatomical structure maturation
regulation of G1/S transition of mitotic cell cycle
positive regulation of mitotic cell cycle
regulation of muscle cell differentiation
regulation of cell cycle G1/S phase transition
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of immune effector process
regulation of I-kappaB kinase/NF-kappaB signaling
nuclear membrane
developmental maturation
positive regulation of cell cycle process
defense response to bacterium
positive regulation of innate immune response
positive regulation of response to biotic stimulus
positive regulation of cell cycle
chromatin binding
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
positive regulation of cytokine production
regulation of innate immune response
regulation of immune effector process
positive regulation of defense response
blood vessel development
positive regulation of multi-organism process