ANKRD1 [The Human Chemical-Genetic Interaction Map Project]

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======= ANKRD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ANKRD1
  * **<color #00a2e8>Official Name</color>**: ankyrin repeat domain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27063|27063]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15327|Q15327]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ANKRD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ANKRD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609599|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. {ECO:0000269|PubMed:15805281, ECO:0000269|PubMed:7730328}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II-specific DNA-binding transcription factor binding|
|titin binding|
|positive regulation of DNA damage response, signal transduction by p53 class mediator|
|response to muscle stretch|
|I band|
|positive regulation of signal transduction by p53 class mediator|
|R-SMAD binding|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|negative regulation of DNA biosynthetic process|
|sarcomere organization|
|RNA polymerase II transcription factor binding|
|myofibril assembly|
|p53 binding|
|cardiac muscle tissue morphogenesis|
|cellular response to mechanical stimulus|
|muscle tissue morphogenesis|
|muscle organ morphogenesis|
|positive regulation of response to DNA damage stimulus|
|cellular component assembly involved in morphogenesis|
|histone deacetylase binding|
|regulation of DNA biosynthetic process|
|actomyosin structure organization|
|negative regulation of DNA metabolic process|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|fibrillar center|
|striated muscle cell development|
|muscle cell development|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|cardiac muscle tissue development|
|cellular response to interleukin-1|
|regulation of signal transduction by p53 class mediator|
|cellular response to lipopolysaccharide|
|cellular response to hypoxia|
|cellular response to molecule of bacterial origin|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|striated muscle cell differentiation|
|response to mechanical stimulus|
|cellular response to biotic stimulus|
|cellular response to oxygen levels|
|regulation of response to DNA damage stimulus|
|cellular response to tumor necrosis factor|
|transcription corepressor activity|
|muscle cell differentiation|
|heart morphogenesis|
|response to tumor necrosis factor|
|positive regulation of protein secretion|
|positive regulation of neuron projection development|
|transcription coactivator activity|
|striated muscle tissue development|
|positive regulation of peptide secretion|
|muscle organ development|
|muscle tissue development|
|response to lipopolysaccharide|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|response to molecule of bacterial origin|
|cellular response to external stimulus|
|response to hypoxia|
|regulation of DNA metabolic process|
|response to decreased oxygen levels|
|positive regulation of neuron differentiation|
|response to oxygen levels|
|positive regulation of cell projection organization|
|regulation of lipid metabolic process|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|muscle structure development|
|actin cytoskeleton organization|
|regulation of peptide secretion|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|cellular response to lipid|
|heart development|
|response to growth factor|
|positive regulation of nervous system development|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|tissue morphogenesis|
|actin filament-based process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of cell projection organization|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|organelle assembly|
|regulation of secretion|
|regulation of neurogenesis|
|cellular component morphogenesis|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|response to cytokine|
|cytoskeleton organization|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17456
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ANKRD1 Expression in NALM6 Cells: -2.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>