ANKRD1

Entrez Summary: The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system. [provided by RefSeq, Jul 2008].
UniProt Summary: May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. {ECO:0000269|PubMed:15805281, ECO:0000269|PubMed:7730328}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ank 2
Ank

RNA polymerase II-specific DNA-binding transcription factor binding
titin binding
positive regulation of DNA damage response, signal transduction by p53 class mediator
response to muscle stretch
I band
positive regulation of signal transduction by p53 class mediator
R-SMAD binding
regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of DNA biosynthetic process
sarcomere organization
RNA polymerase II transcription factor binding
myofibril assembly
p53 binding
cardiac muscle tissue morphogenesis
cellular response to mechanical stimulus
muscle tissue morphogenesis
muscle organ morphogenesis
positive regulation of response to DNA damage stimulus
cellular component assembly involved in morphogenesis
histone deacetylase binding
regulation of DNA biosynthetic process
actomyosin structure organization
negative regulation of DNA metabolic process
skeletal muscle tissue development
skeletal muscle organ development
fibrillar center
striated muscle cell development
muscle cell development
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
cardiac muscle tissue development
cellular response to interleukin-1
regulation of signal transduction by p53 class mediator
cellular response to lipopolysaccharide
cellular response to hypoxia
cellular response to molecule of bacterial origin
cellular response to decreased oxygen levels
response to interleukin-1
striated muscle cell differentiation
response to mechanical stimulus